5LUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lup by Molmil](/molmil-images/mine/5lup) | Structures of DHBN domain of human BLM helicase | 分子名称: | BLM protein, PHOSPHATE ION, POTASSIUM ION | 著者 | Shi, J, Chen, W.-F, Zhang, B, Fan, S.-H, Ai, X, Liu, N.-N, Rety, S, Xi, X.-G. | 登録日 | 2016-09-09 | 公開日 | 2017-03-01 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.032 Å) | 主引用文献 | A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation. J. Biol. Chem., 292, 2017
|
|
2ZN7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2zn7 by Molmil](/molmil-images/mine/2zn7) | CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes | 分子名称: | 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(phenylcarbonyl)amino]phenyl}thiophene-2-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Xu, W, Wu, J. | 登録日 | 2008-04-22 | 公開日 | 2008-10-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24 Chemmedchem, 3, 2008
|
|
5M0E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m0e by Molmil](/molmil-images/mine/5m0e) | Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors | 分子名称: | 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | 著者 | Keune, W.-J, Heidebrecht, T, Perrakis, A. | 登録日 | 2016-10-04 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators. J. Med. Chem., 60, 2017
|
|
5DZ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dz2 by Molmil](/molmil-images/mine/5dz2) | Geosmin synthase from Streptomyces coelicolor N-terminal domain complexed with three Mg2+ ions and alendronic acid | 分子名称: | ALENDRONATE, Germacradienol/geosmin synthase, MAGNESIUM ION | 著者 | Harris, G.G, Lombardi, P.M, Pemberton, T.A, Matsui, T, Weiss, T.M, Cole, K.E, Koksal, M, Murphy, F.V, Vedula, L.S, Chou, W.K.W, Cane, D.E, Christianson, D.W. | 登録日 | 2015-09-25 | 公開日 | 2015-12-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.111 Å) | 主引用文献 | Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with alpha alpha Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence. Biochemistry, 54, 2015
|
|
2MAD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mad by Molmil](/molmil-images/mine/2mad) | |
2TSR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2tsr by Molmil](/molmil-images/mine/2tsr) | THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE, TOMUDEX | 著者 | Sotelo-Mundo, R.R, Ciesla, J, Dzik, J.M, Rode, W, Maley, F, Maley, G, Hardy, L.W, Montfort, W.R. | 登録日 | 1998-06-19 | 公開日 | 1999-02-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug. Biochemistry, 38, 1999
|
|
6RTD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6rtd by Molmil](/molmil-images/mine/6rtd) | Dihydro-heme d1 dehydrogenase NirN in complex with DHE | 分子名称: | (R,R)-2,3-BUTANEDIOL, Cytochrome c, HEME C, ... | 著者 | Kluenemann, T, Preuss, A, Layer, G, Blankenfeldt, W. | 登録日 | 2019-05-23 | 公開日 | 2019-06-19 | 最終更新日 | 2019-08-28 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Crystal Structure of Dihydro-Heme d1Dehydrogenase NirN from Pseudomonas aeruginosa Reveals Amino Acid Residues Essential for Catalysis. J.Mol.Biol., 431, 2019
|
|
7OVC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ovc by Molmil](/molmil-images/mine/7ovc) | Structure of the human UFC1 protein in complex with the UBA5 C-terminal UFC1-binding motif. | 分子名称: | Ubiquitin-fold modifier-conjugating enzyme 1, Ubiquitin-like modifier-activating enzyme 5 | 著者 | Wesch, W, Loehr, F, Rogova, N, Doetsch, V, Rogov, V.V. | 登録日 | 2021-06-14 | 公開日 | 2021-08-04 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1. Int J Mol Sci, 22, 2021
|
|
4B99
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4b99 by Molmil](/molmil-images/mine/4b99) | Crystal Structure of MAPK7 (ERK5) with inhibitor | 分子名称: | 11-cyclopentyl-2-[[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl-phenyl]amino]-5-methyl-pyrimido[4,5-b][1,4]benzodiazepin-6-one, MITOGEN-ACTIVATED PROTEIN KINASE 7 | 著者 | Elkins, J.M, Wang, J, Vollmar, M, Mahajan, P, Savitsky, P, Deng, X, Gray, N.S, Pike, A.C.W, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A, Knapp, S. | 登録日 | 2012-09-03 | 公開日 | 2012-09-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | X-Ray Crystal Structure of Erk5 (Mapk7) in Complex with a Specific Inhibitor. J.Med.Chem., 56, 2013
|
|
3ISQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3isq by Molmil](/molmil-images/mine/3isq) | Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase | 分子名称: | 1,2-ETHANEDIOL, 4-hydroxyphenylpyruvate dioxygenase, CHLORIDE ION, ... | 著者 | Pilka, E.S, Shafqat, N, Cocking, R, Bray, J.E, Krojer, T, Pike, A.C.W, von Delft, F, Yue, W.W, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U, Kavanagh, K.L, Structural Genomics Consortium (SGC) | 登録日 | 2009-08-27 | 公開日 | 2009-09-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase to be published
|
|
6RUO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ruo by Molmil](/molmil-images/mine/6ruo) | RNA Polymerase I Open Complex conformation 1 | 分子名称: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | 著者 | Mueller, C.W, Sadian, Y, Tafur, L. | 登録日 | 2019-05-28 | 公開日 | 2019-12-11 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Molecular insight into RNA polymerase I promoter recognition and promoter melting. Nat Commun, 10, 2019
|
|
4BKR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bkr by Molmil](/molmil-images/mine/4bkr) | Enoyl-ACP reductase from Yersinia pestis (wildtype, removed Histag) with cofactor NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Hirschbeck, M.W, Neckles, C, Tonge, P.J, Kisker, C. | 登録日 | 2013-04-29 | 公開日 | 2014-05-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia Pestis Fabv Enoyl-Acp Reductase. Biochemistry, 55, 2016
|
|
5M4Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m4z by Molmil](/molmil-images/mine/5m4z) | Crystal structure of the complex of T.spiralis thymidylate synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, crystallized in the presence of N(5,10)-methylenetetrahydrofolate | 分子名称: | GLYCEROL, Thymidylate synthase, [(2~{R},3~{S},5~{R})-5-[(4~{E})-4-hydroxyimino-2-oxidanylidene-1,3-diazinan-1-yl]-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | 著者 | Wilk, P, Maj, P, Jarmula, A, Dowiercial, A, Rode, W. | 登録日 | 2016-10-19 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.179 Å) | 主引用文献 | Molecular Mechanism of Thymidylate Synthase Inhibition by N 4 -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies. Int J Mol Sci, 22, 2021
|
|
5M70
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m70 by Molmil](/molmil-images/mine/5m70) | Crystal Structure of human RhoGAP mutated in its arginin finger (R85A) in complex with RhoA.GDP.AlF4- human | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase-activating protein 1, ... | 著者 | Pellegrini, E, Bowler, M.W. | 登録日 | 2016-10-26 | 公開日 | 2017-05-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, (19) F NMR, and DFT Approaches. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
1WVE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wve by Molmil](/molmil-images/mine/1wve) | p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon its Binding to the Cytochrome Subunit | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-cresol dehydrogenase [hydroxylating] cytochrome c subunit, 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit, ... | 著者 | Cunane, L.M, Chen, Z.-W, McIntire, W.S, Mathews, F.S. | 登録日 | 2004-12-15 | 公開日 | 2005-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon Its Binding to the Cytochrome Subunit Biochemistry, 44, 2005
|
|
8EPQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8epq by Molmil](/molmil-images/mine/8epq) | |
5MD7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5md7 by Molmil](/molmil-images/mine/5md7) | The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=11, twist=-12 | 分子名称: | Capsid protein p24 | 著者 | Mattei, S, Glass, B, Hagen, W.J.H, Kraeusslich, H.-G, Briggs, J.A.G. | 登録日 | 2016-11-10 | 公開日 | 2016-12-28 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (8.4 Å) | 主引用文献 | The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science, 354, 2016
|
|
4B96
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4b96 by Molmil](/molmil-images/mine/4b96) | Family 3b carbohydrate-binding module from the biomass sensoring system of Clostridium clariflavum | 分子名称: | CALCIUM ION, CELLULOSE BINDING DOMAIN-CONTAINING PROTEIN, CHLORIDE ION | 著者 | Yaniv, O, Reddy, Y.H.K, Yoffe, H, Shimon, L.J.W, Bayer, E.A, Lamed, R, Frolow, F. | 登録日 | 2012-09-02 | 公開日 | 2013-09-18 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.911 Å) | 主引用文献 | Structure of Cbm3B from the Biomass Sensoring System of Clostridium Clarifalvum To be Published
|
|
5M8N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m8n by Molmil](/molmil-images/mine/5m8n) | Crystal structure of human tyrosinase related protein 1 in complex with mimosine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | 登録日 | 2016-10-29 | 公開日 | 2017-07-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5MD9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5md9 by Molmil](/molmil-images/mine/5md9) | The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=17, twist=6 | 分子名称: | Capsid protein p24 C-terminal domain, Capsid protein p24 N-terminal domain | 著者 | Mattei, S, Glass, B, Hagen, W.J.H, Kraeusslich, H.-G, Briggs, J.A.G. | 登録日 | 2016-11-10 | 公開日 | 2016-12-28 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (8 Å) | 主引用文献 | The structure and flexibility of conical HIV-1 capsids determined within intact virions. Science, 354, 2016
|
|
8EPP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8epp by Molmil](/molmil-images/mine/8epp) | |
2NAE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2nae by Molmil](/molmil-images/mine/2nae) | |
4CLA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cla by Molmil](/molmil-images/mine/4cla) | |
8ELJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8elj by Molmil](/molmil-images/mine/8elj) | SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ICO-hu23 antibody Fab heavy chain, ... | 著者 | Yee, A.W, Morizumi, T, Kim, K, Kuo, A, Ernst, O.P. | 登録日 | 2022-09-24 | 公開日 | 2023-07-19 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates. Plos Pathog., 19, 2023
|
|
376D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 376d by Molmil](/molmil-images/mine/376d) | A ZIPPER-LIKE DNA DUPLEX D(GCGAAAGCT) | 分子名称: | COBALT HEXAMMINE(III), DNA (5'-D(*GP*(CBR)P*GP*AP*AP*AP*GP*CP*T)-3') | 著者 | Cruse, W.B.T, Shepard, W, Prange, T, delalFortelle, E, Fourme, R. | 登録日 | 1998-01-22 | 公開日 | 1999-10-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A zipper-like duplex in DNA: the crystal structure of d(GCGAAAGCT) at 2.1 A resolution. Structure, 6, 1998
|
|