8ELJ

SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment

Summary for 8ELJ

• Entry DOI: 10.2210/pdb8elj/pdb
• EMDB information: 28228
• Descriptor: Spike glycoprotein, ICO-hu23 antibody Fab heavy chain, ICO-hu23 antibody Fab light chain, ... (5 entities in total)
• Functional Keywords: complex, antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 9
• Total formula weight: 574276.48

Authors

Yee, A.W.,Morizumi, T.,Kim, K.,Kuo, A.,Ernst, O.P. (deposition date: 2022-09-24, release date: 2023-07-19, Last modification date: 2023-08-16)

• Primary citation: Hermet, P.,Delache, B.,Herate, C.,Wolf, E.,Kivi, G.,Juronen, E.,Mumm, K.,Zusinaite, E.,Kainov, D.,Sankovski, E.,Virumae, K.,Planken, A.,Merits, A.,Besaw, J.E.,Yee, A.W.,Morizumi, T.,Kim, K.,Kuo, A.,Berriche, A.,Dereuddre-Bosquet, N.,Sconosciuti, Q.,Naninck, T.,Relouzat, F.,Cavarelli, M.,Ustav, M.,Wilson, D.,Ernst, O.P.,Mannik, A.,LeGrand, R.,Ustav Jr., M.; Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates.; Plos Pathog., 19:e1011532-e1011532, 2023; PubMed: 37531329; DOI: 10.1371/journal.ppat.1011532

Experimental method

ELECTRON MICROSCOPY (3.6 Å)