8ELJ
SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Spike glycoprotein | polymer | 1256 | 139234.1 | 3 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
| 2 | D, F, H (S, U, W) | ICO-hu23 antibody Fab heavy chain | polymer | 234 | 25479.6 | 3 | Homo sapiens (Human) | ||
| 3 | E, G, I (T, V, X) | ICO-hu23 antibody Fab light chain | polymer | 216 | 22802.1 | 3 | Homo sapiens (Human) | ||
| 4 | J, K, L, M, N... (E, F, G, H, J...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | In PDB GlyTouCan (G42666HT) | |||
| 5 | AA, BA, CA, DA, EA... (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 30 | Chemie (NAG) |
Sequence modifications
A, B, C: 13 - 1211 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| Lys -5 | - | expression tag |
| Trp -4 | - | expression tag |
| Val -3 | - | expression tag |
| Thr -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Ile 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Leu 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Phe 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Phe 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Ser 8 | - | expression tag |
| Ala 9 | - | expression tag |
| Tyr 10 | - | expression tag |
| Ser 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Gly 682 | Arg 682 | conflict |
| Ser 683 | Arg 683 | conflict |
| Ser 685 | Arg 685 | conflict |
| Pro 986 | Lys 986 | conflict |
| Pro 987 | Val 987 | conflict |
| Gly 1212 | - | expression tag |
| Ser 1213 | - | expression tag |
| Gly 1214 | - | expression tag |
| Tyr 1215 | - | expression tag |
| Ile 1216 | - | expression tag |
| Pro 1217 | - | expression tag |
| Glu 1218 | - | expression tag |
| Ala 1219 | - | expression tag |
| Pro 1220 | - | expression tag |
| Arg 1221 | - | expression tag |
| Asp 1222 | - | expression tag |
| Gly 1223 | - | expression tag |
| Gln 1224 | - | expression tag |
| Ala 1225 | - | expression tag |
| Tyr 1226 | - | expression tag |
| Val 1227 | - | expression tag |
| Arg 1228 | - | expression tag |
| Lys 1229 | - | expression tag |
| Asp 1230 | - | expression tag |
| Gly 1231 | - | expression tag |
| Glu 1232 | - | expression tag |
| Trp 1233 | - | expression tag |
| Val 1234 | - | expression tag |
| Leu 1235 | - | expression tag |
| Leu 1236 | - | expression tag |
| Ser 1237 | - | expression tag |
| Thr 1238 | - | expression tag |
| Phe 1239 | - | expression tag |
| Leu 1240 | - | expression tag |
| Gly 1241 | - | expression tag |
| Ser 1242 | - | expression tag |
| Gly 1243 | - | expression tag |
| His 1244 | - | expression tag |
| His 1245 | - | expression tag |
| His 1246 | - | expression tag |
| His 1247 | - | expression tag |
| His 1248 | - | expression tag |
| His 1249 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 562547.4 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 5092.8 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 6636.2 | |
| All* | Total formula weight | 574276.5 |
