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2ZN7

CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes

Summary for 2ZN7
Entry DOI10.2210/pdb2zn7/pdb
Related2BO7 2QBQ 2ZMM
DescriptorTyrosine-protein phosphatase non-receptor type 1, 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(phenylcarbonyl)amino]phenyl}thiophene-2-carboxylic acid (3 entities in total)
Functional Keywordsptp1b, protein-inhibitor complex, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase
Biological sourceHomo sapiens (Human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains1
Total formula weight35392.16
Authors
Xu, W.,Wu, J. (deposition date: 2008-04-22, release date: 2008-10-07, Last modification date: 2023-11-01)
Primary citationWan, Z.-K.,Lee, J.,Hotchandani, R.,Moretto, A.,Binnun, E.,Wilson, D.P.,Kirincich, S.J.,Follows, B.C.,Ipek, M.,Xu, W.,Joseph-McCarthy, D.,Zhang, Y.-L.,Tam, M.,Erbe, D.V.,Tobin, J.F.,Li, W.,Tam, S.Y.,Mansour, T.S.,Wu, J.
Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24
Chemmedchem, 3:1525-1529, 2008
Cited by
PubMed: 18798205
DOI: 10.1002/cmdc.200800188
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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