2ZN7
CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes
Summary for 2ZN7
Entry DOI | 10.2210/pdb2zn7/pdb |
Related | 2BO7 2QBQ 2ZMM |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(phenylcarbonyl)amino]phenyl}thiophene-2-carboxylic acid (3 entities in total) |
Functional Keywords | ptp1b, protein-inhibitor complex, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35392.16 |
Authors | |
Primary citation | Wan, Z.-K.,Lee, J.,Hotchandani, R.,Moretto, A.,Binnun, E.,Wilson, D.P.,Kirincich, S.J.,Follows, B.C.,Ipek, M.,Xu, W.,Joseph-McCarthy, D.,Zhang, Y.-L.,Tam, M.,Erbe, D.V.,Tobin, J.F.,Li, W.,Tam, S.Y.,Mansour, T.S.,Wu, J. Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24 Chemmedchem, 3:1525-1529, 2008 Cited by PubMed: 18798205DOI: 10.1002/cmdc.200800188 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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