2TSR

THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX

Summary for 2TSR

• Entry DOI: 10.2210/pdb2tsr/pdb
• Descriptor: THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, ... (4 entities in total)
• Functional Keywords: thymidylate synthase, methyltransferase, dump, tomudex, antifolate
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Nucleus : P45352
• Total number of polymer chains: 4
• Total formula weight: 143306.77

Authors

Sotelo-Mundo, R.R.,Ciesla, J.,Dzik, J.M.,Rode, W.,Maley, F.,Maley, G.,Hardy, L.W.,Montfort, W.R. (deposition date: 1998-06-19, release date: 1999-02-16, Last modification date: 2024-02-21)

• Primary citation: Sotelo-Mundo, R.R.,Ciesla, J.,Dzik, J.M.,Rode, W.,Maley, F.,Maley, G.F.,Hardy, L.W.,Montfort, W.R.; Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug.; Biochemistry, 38:1087-1094, 1999; PubMed: 9894005; DOI: 10.1021/bi981881d

Experimental method

X-RAY DIFFRACTION (2.6 Å)