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2TSR

THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0000900molecular_functionmRNA regulatory element binding translation repressor activity
A0003729molecular_functionmRNA binding
A0004799molecular_functionthymidylate synthase activity
A0005542molecular_functionfolic acid binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006206biological_processpyrimidine nucleobase metabolic process
A0006231biological_processdTMP biosynthetic process
A0006235biological_processdTTP biosynthetic process
A0006417biological_processregulation of translation
A0007623biological_processcircadian rhythm
A0008168molecular_functionmethyltransferase activity
A0009165biological_processnucleotide biosynthetic process
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0014070biological_processresponse to organic cyclic compound
A0016741molecular_functiontransferase activity, transferring one-carbon groups
A0017148biological_processnegative regulation of translation
A0019860biological_processuracil metabolic process
A0032259biological_processmethylation
A0032570biological_processresponse to progesterone
A0033189biological_processresponse to vitamin A
A0034097biological_processresponse to cytokine
A0035999biological_processtetrahydrofolate interconversion
A0042803molecular_functionprotein homodimerization activity
A0045471biological_processresponse to ethanol
A0046653biological_processtetrahydrofolate metabolic process
A0046683biological_processresponse to organophosphorus
A0048589biological_processdevelopmental growth
A0051216biological_processcartilage development
A0051384biological_processresponse to glucocorticoid
A0051593biological_processresponse to folic acid
A0060574biological_processintestinal epithelial cell maturation
A0097421biological_processliver regeneration
A1901363molecular_functionheterocyclic compound binding
A1990825molecular_functionsequence-specific mRNA binding
B0000900molecular_functionmRNA regulatory element binding translation repressor activity
B0003729molecular_functionmRNA binding
B0004799molecular_functionthymidylate synthase activity
B0005542molecular_functionfolic acid binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006206biological_processpyrimidine nucleobase metabolic process
B0006231biological_processdTMP biosynthetic process
B0006235biological_processdTTP biosynthetic process
B0006417biological_processregulation of translation
B0007623biological_processcircadian rhythm
B0008168molecular_functionmethyltransferase activity
B0009165biological_processnucleotide biosynthetic process
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0014070biological_processresponse to organic cyclic compound
B0016741molecular_functiontransferase activity, transferring one-carbon groups
B0017148biological_processnegative regulation of translation
B0019860biological_processuracil metabolic process
B0032259biological_processmethylation
B0032570biological_processresponse to progesterone
B0033189biological_processresponse to vitamin A
B0034097biological_processresponse to cytokine
B0035999biological_processtetrahydrofolate interconversion
B0042803molecular_functionprotein homodimerization activity
B0045471biological_processresponse to ethanol
B0046653biological_processtetrahydrofolate metabolic process
B0046683biological_processresponse to organophosphorus
B0048589biological_processdevelopmental growth
B0051216biological_processcartilage development
B0051384biological_processresponse to glucocorticoid
B0051593biological_processresponse to folic acid
B0060574biological_processintestinal epithelial cell maturation
B0097421biological_processliver regeneration
B1901363molecular_functionheterocyclic compound binding
B1990825molecular_functionsequence-specific mRNA binding
C0000900molecular_functionmRNA regulatory element binding translation repressor activity
C0003729molecular_functionmRNA binding
C0004799molecular_functionthymidylate synthase activity
C0005542molecular_functionfolic acid binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0006206biological_processpyrimidine nucleobase metabolic process
C0006231biological_processdTMP biosynthetic process
C0006235biological_processdTTP biosynthetic process
C0006417biological_processregulation of translation
C0007623biological_processcircadian rhythm
C0008168molecular_functionmethyltransferase activity
C0009165biological_processnucleotide biosynthetic process
C0009410biological_processresponse to xenobiotic stimulus
C0009636biological_processresponse to toxic substance
C0014070biological_processresponse to organic cyclic compound
C0016741molecular_functiontransferase activity, transferring one-carbon groups
C0017148biological_processnegative regulation of translation
C0019860biological_processuracil metabolic process
C0032259biological_processmethylation
C0032570biological_processresponse to progesterone
C0033189biological_processresponse to vitamin A
C0034097biological_processresponse to cytokine
C0035999biological_processtetrahydrofolate interconversion
C0042803molecular_functionprotein homodimerization activity
C0045471biological_processresponse to ethanol
C0046653biological_processtetrahydrofolate metabolic process
C0046683biological_processresponse to organophosphorus
C0048589biological_processdevelopmental growth
C0051216biological_processcartilage development
C0051384biological_processresponse to glucocorticoid
C0051593biological_processresponse to folic acid
C0060574biological_processintestinal epithelial cell maturation
C0097421biological_processliver regeneration
C1901363molecular_functionheterocyclic compound binding
C1990825molecular_functionsequence-specific mRNA binding
D0000900molecular_functionmRNA regulatory element binding translation repressor activity
D0003729molecular_functionmRNA binding
D0004799molecular_functionthymidylate synthase activity
D0005542molecular_functionfolic acid binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0006206biological_processpyrimidine nucleobase metabolic process
D0006231biological_processdTMP biosynthetic process
D0006235biological_processdTTP biosynthetic process
D0006417biological_processregulation of translation
D0007623biological_processcircadian rhythm
D0008168molecular_functionmethyltransferase activity
D0009165biological_processnucleotide biosynthetic process
D0009410biological_processresponse to xenobiotic stimulus
D0009636biological_processresponse to toxic substance
D0014070biological_processresponse to organic cyclic compound
D0016741molecular_functiontransferase activity, transferring one-carbon groups
D0017148biological_processnegative regulation of translation
D0019860biological_processuracil metabolic process
D0032259biological_processmethylation
D0032570biological_processresponse to progesterone
D0033189biological_processresponse to vitamin A
D0034097biological_processresponse to cytokine
D0035999biological_processtetrahydrofolate interconversion
D0042803molecular_functionprotein homodimerization activity
D0045471biological_processresponse to ethanol
D0046653biological_processtetrahydrofolate metabolic process
D0046683biological_processresponse to organophosphorus
D0048589biological_processdevelopmental growth
D0051216biological_processcartilage development
D0051384biological_processresponse to glucocorticoid
D0051593biological_processresponse to folic acid
D0060574biological_processintestinal epithelial cell maturation
D0097421biological_processliver regeneration
D1901363molecular_functionheterocyclic compound binding
D1990825molecular_functionsequence-specific mRNA binding
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE UMP A 308
ChainResidue
AHIS250
ATYR252
AD16309
AHOH329
BARG169
AARG44
ACYS189
AHIS190
AARG209
ASER210
AASP212
AGLY216
AASN220

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE UMP B 408
ChainResidue
AARG169
AARG170
BARG44
BCYS189
BHIS190
BARG209
BSER210
BGLY211
BASP212
BASN220
BHIS250
BTYR252
BD16409

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE UMP C 508
ChainResidue
CARG44
CCYS189
CHIS190
CARG209
CSER210
CASP212
CGLY216
CASN220
CHIS250
CD16509
DARG169
DARG170

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE UMP D 608
ChainResidue
CARG169
CARG170
DARG44
DPRO187
DCYS189
DHIS190
DGLN208
DARG209
DSER210
DGLY211
DASP212
DASN220
DHIS250
DTYR252
DD16609
DHOH616

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE D16 A 309
ChainResidue
AARG72
AILE102
AASP212
AGLY216
APHE219
AUMP308

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE D16 B 409
ChainResidue
BARG101
BILE102
BTRP103
BASP212
BGLY216
BPHE219
BTYR252
BUMP408

site_idAC7
Number of Residues10
DetailsBINDING SITE FOR RESIDUE D16 C 509
ChainResidue
CARG72
CILE102
CTRP103
CASP212
CLEU215
CGLY216
CPHE219
CTYR252
CUMP508
CHOH510

site_idAC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE D16 D 609
ChainResidue
DPHE74
DASP212
DLEU215
DGLY216
DPHE219
DTYR252
DUMP608

site_idNUL
Number of Residues1
DetailsCATALYTIC RESIDUE, EQUIVALENT TO C146 IN ESCHERICHIA COLI THYMIDYLATE SYNTHASE.
ChainResidue
ACYS189

Functional Information from PROSITE/UniProt
site_idPS00091
Number of Residues29
DetailsTHYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImcaWNpkdlplma.....LpPCHalcQFyV
ChainResidueDetails
AARG169-VAL197

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884
ChainResidueDetails
ACYS189
BCYS189
CCYS189
DCYS189

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: in other chain => ECO:0000269|PubMed:9894005, ECO:0007744|PDB:1RTS, ECO:0007744|PDB:2TSR
ChainResidueDetails
AARG44
BHIS250
CARG44
CCYS189
CARG209
CASN220
CHIS250
DARG44
DCYS189
DARG209
DASN220
ACYS189
DHIS250
AARG209
AASN220
AHIS250
BARG44
BCYS189
BARG209
BASN220

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:9894005, ECO:0007744|PDB:1RTS, ECO:0007744|PDB:2TSR
ChainResidueDetails
AARG169
BARG169
CARG169
DARG169

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P0A884
ChainResidueDetails
AASP212
AALA306
BASP212
BALA306
CASP212
CALA306
DASP212
DALA306

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04818
ChainResidueDetails
ASER108
BSER108
CSER108
DSER108

site_idSWS_FT_FI6
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P04818
ChainResidueDetails
ALYS286
DLYS286
DLYS302
ALYS302
BLYS286
BLYS302
CLYS286
CLYS302

Catalytic Information from CSA
site_idCSA1
Number of Residues6
DetailsAnnotated By Reference To The Literature 1b02
ChainResidueDetails
AGLU81
AASP212
AASP248
ACYS189
ASER210
AHIS250

site_idCSA2
Number of Residues6
DetailsAnnotated By Reference To The Literature 1b02
ChainResidueDetails
BGLU81
BASP212
BASP248
BCYS189
BSER210
BHIS250

site_idCSA3
Number of Residues6
DetailsAnnotated By Reference To The Literature 1b02
ChainResidueDetails
CGLU81
CASP212
CASP248
CCYS189
CSER210
CHIS250

site_idCSA4
Number of Residues6
DetailsAnnotated By Reference To The Literature 1b02
ChainResidueDetails
DGLU81
DASP212
DASP248
DCYS189
DSER210
DHIS250

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b02
ChainResidueDetails
ASER223
ACYS189
AASN220

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b02
ChainResidueDetails
BSER223
BCYS189
BASN220

site_idCSA7
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b02
ChainResidueDetails
CSER223
CCYS189
CASN220

site_idCSA8
Number of Residues3
DetailsAnnotated By Reference To The Literature 1b02
ChainResidueDetails
DSER223
DCYS189
DASN220

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PDB entries from 2024-08-28

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