6TED
 
 | | Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric elongation activation by RTF1 | | Descriptor: | DNA (37-MER), DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, ... | | Authors: | Vos, S.M, Farnung, L, Cramer, P. | | Deposit date: | 2019-11-11 | | Release date: | 2020-07-22 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation.
Nat.Struct.Mol.Biol., 27, 2020
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4TMA
 | | Crystal structure of gyrase bound to its inhibitor YacG | | Descriptor: | DNA gyrase inhibitor YacG, DNA gyrase subunit A, DNA gyrase subunit B, ... | | Authors: | Vos, S.M, Lyubimov, A.Y, Hershey, D.M, Schoeffler, A.J, Berger, J.M. | | Deposit date: | 2014-05-31 | | Release date: | 2014-07-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein.
Genes Dev., 28, 2014
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6GMH
 | | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | | Descriptor: | CDC73, CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog, DNA-directed RNA polymerase II subunit RPB9, ... | | Authors: | Vos, S.M, Farnung, L, Boehing, M, Linden, A, Wigge, C, Urlaub, H, Cramer, P. | | Deposit date: | 2018-05-26 | | Release date: | 2018-08-22 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
Nature, 560, 2018
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4MN4
 | | Structural Basis for the MukB-topoisomerase IV Interaction | | Descriptor: | Chromosome partition protein MukB, DNA topoisomerase 4 subunit A | | Authors: | Vos, S.M, Stewart, N.K, Oakley, M.G, Berger, J.M. | | Deposit date: | 2013-09-09 | | Release date: | 2013-10-23 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for the MukB-topoisomerase IV interaction and its functional implications in vivo.
Embo J., 32, 2013
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8UHA
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8UI0
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8UHG
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6GML
 | | Structure of paused transcription complex Pol II-DSIF-NELF | | Descriptor: | DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Vos, S.M, Farnung, L, Urlaub, H, Cramer, P. | | Deposit date: | 2018-05-27 | | Release date: | 2018-09-05 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of paused transcription complex Pol II-DSIF-NELF.
Nature, 560, 2018
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6GME
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1NUL
 | | XPRTASE FROM E. COLI | | Descriptor: | MAGNESIUM ION, SULFATE ION, XANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE | | Authors: | Vos, S, De Jersey, J, Martin, J.L. | | Deposit date: | 1996-10-15 | | Release date: | 1997-05-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of Escherichia coli xanthine phosphoribosyltransferase.
Biochemistry, 36, 1997
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1A98
 | | XPRTASE FROM E. COLI COMPLEXED WITH GMP | | Descriptor: | XANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE | | Authors: | Vos, S, Parry, R.J, Burns, M.R, De Jersey, J, Martin, J.L. | | Deposit date: | 1998-04-16 | | Release date: | 1998-06-17 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase.
J.Mol.Biol., 282, 1998
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1A96
 | | XPRTASE FROM E. COLI WITH BOUND CPRPP AND XANTHINE | | Descriptor: | 1-ALPHA-PYROPHOSPHORYL-2-ALPHA,3-ALPHA-DIHYDROXY-4-BETA-CYCLOPENTANE-METHANOL-5-PHOSPHATE, BORIC ACID, MAGNESIUM ION, ... | | Authors: | Vos, S, Parry, R.J, Burns, M.R, De Jersey, J, Martin, J.L. | | Deposit date: | 1998-04-16 | | Release date: | 1998-11-11 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase.
J.Mol.Biol., 282, 1998
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1A97
 | | XPRTASE FROM E. COLI COMPLEXED WITH GMP | | Descriptor: | BORIC ACID, GUANOSINE-5'-MONOPHOSPHATE, XANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE | | Authors: | Vos, S, Parry, R.J, Burns, M.R, De Jersey, J, Martin, J.L. | | Deposit date: | 1998-04-16 | | Release date: | 1998-11-11 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase.
J.Mol.Biol., 282, 1998
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1A95
 | | XPRTASE FROM E. COLI COMPLEXED WITH MG:CPRPP AND GUANINE | | Descriptor: | 1-ALPHA-PYROPHOSPHORYL-2-ALPHA,3-ALPHA-DIHYDROXY-4-BETA-CYCLOPENTANE-METHANOL-5-PHOSPHATE, BORIC ACID, GUANINE, ... | | Authors: | Vos, S, Parry, R.J, Burns, M.R, De Jersey, J, Martin, J.L. | | Deposit date: | 1998-04-16 | | Release date: | 1998-11-11 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase.
J.Mol.Biol., 282, 1998
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4YSI
 | | Structure of USP7 with a novel viral protein | | Descriptor: | GLYCEROL, SER-PRO-GLY-GLU-GLY-PRO-SER-GLY, Ubiquitin carboxyl-terminal hydrolase 7 | | Authors: | Chavoshi, S, Saridakis, V. | | Deposit date: | 2015-03-17 | | Release date: | 2016-02-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.02 Å) | | Cite: | Structure of USP7 with a novel viral protein
J.Biol.Chem., 2016
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5O9G
 | | Structure of nucleosome-Chd1 complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | | Authors: | Farnung, L, Vos, S.M, Wigge, C, Cramer, P. | | Deposit date: | 2017-06-19 | | Release date: | 2017-10-11 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Nucleosome-Chd1 structure and implications for chromatin remodelling.
Nature, 550, 2017
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8A40
 | | Structure of mammalian Pol II-TFIIS elongation complex | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Farnung, L, Ochmann, M, Garg, G, Vos, S.M, Cramer, P. | | Deposit date: | 2022-06-09 | | Release date: | 2023-08-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of a backtracked hexasomal intermediate of nucleosome transcription.
Mol.Cell, 82, 2022
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7UNC
 | | Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Filipovski, M, Vos, S.M, Farnung, L. | | Deposit date: | 2022-04-10 | | Release date: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of nucleosome retention during transcription elongation.
Science, 376, 2022
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7UND
 | | Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Filipovski, M, Vos, S.M, Farnung, L. | | Deposit date: | 2022-04-10 | | Release date: | 2022-10-19 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of nucleosome retention during transcription elongation.
Science, 376, 2022
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3B9G
 | | Crystal structure of loop deletion mutant of Trypanosoma vivax nucleoside hydrolase (3GTvNH) in complex with ImmH | | Descriptor: | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, CALCIUM ION, IAG-nucleoside hydrolase, ... | | Authors: | Vandemeulebroucke, A, De Vos, S, Van Holsbeke, E, Steyaert, J, Versees, W. | | Deposit date: | 2007-11-05 | | Release date: | 2008-04-22 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | A Flexible Loop as a Functional Element in the Catalytic Mechanism of Nucleoside Hydrolase from Trypanosoma vivax.
J.Biol.Chem., 283, 2008
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5L3X
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7B0Y
 | | Structure of a transcribing RNA polymerase II-U1 snRNP complex | | Descriptor: | 145-nt RNA, DNA-directed RNA polymerase II subunit D, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Zhang, S, Aibara, S, Vos, S.M, Agafonov, D.E, Luehrmann, R, Cramer, P. | | Deposit date: | 2020-11-23 | | Release date: | 2021-01-13 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of a transcribing RNA polymerase II-U1 snRNP complex.
Science, 371, 2021
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8UIS
 | | Structure of transcription complex Pol II-DSIF-NELF-TFIIS | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Su, B.G, Vos, S.M. | | Deposit date: | 2023-10-10 | | Release date: | 2024-03-20 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Mol.Cell, 84, 2024
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8UHD
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8TOF
 | | Rpd3S bound to an H3K36Cme3 modified nucleosome | | Descriptor: | Chromatin modification-related protein EAF3, DNA (176-MER), Histone H2A, ... | | Authors: | Markert, J.W, Vos, S.M, Farnung, L. | | Deposit date: | 2023-08-03 | | Release date: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex.
Nat Commun, 14, 2023
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