6GKQ
 
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6GKU
 | | Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 6F5 | | Descriptor: | CALCIUM ION, Fab 6F5 - Heavy Chain, Fab 6F5 - Light chain, ... | | Authors: | Verstraete, K, Verschueren, K, Savvides, S.N. | | Deposit date: | 2018-05-21 | | Release date: | 2019-06-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6HXJ
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6HXQ
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6HXK
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6HXI
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6HXO
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6HXH
 | | Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase,Human ATP citrate lyase, CITRATE ANION, ... | | Authors: | Verstraete, K, Verschueren, K. | | Deposit date: | 2018-10-17 | | Release date: | 2019-04-10 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
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6HXL
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6HXP
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6HXN
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6HXM
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7OPB
 | | IL7R in complex with an antagonist | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IL7R binder, ... | | Authors: | Markovic, I, Verschueren, K.H.G, Verstraete, K, Savvides, S.N. | | Deposit date: | 2021-05-31 | | Release date: | 2022-05-11 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.144 Å) | | Cite: | Design of protein-binding proteins from the target structure alone.
Nature, 605, 2022
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7Z3P
 | | Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution. | | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Leptin, ... | | Authors: | Tsirigotaki, A, Verschueren, K, Savvides, S.N, Verstraete, K. | | Deposit date: | 2022-03-02 | | Release date: | 2023-03-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.943 Å) | | Cite: | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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6Z2H
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6ZNW
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5MJ3
 | | INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 1 | | Descriptor: | ALPHABODY MA12, Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ... | | Authors: | Desmet, J, Verstraete, K, Bloch, Y, Lorent, E, Wen, Y, Devreese, B, Vandenbroucke, K, Loverix, S, Hettmann, T, Deroo, S, Somers, K, Hendrikx, P, Lasters, I, Savvides, S.N. | | Deposit date: | 2016-11-29 | | Release date: | 2017-01-11 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Structural Basis Of Il-23 Antagonism By An Alphabody Protein Scaffold.
Nat Commun, 5, 2014
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5MJ4
 | | INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 2 | | Descriptor: | ALPHABODY MA12, Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ... | | Authors: | Desmet, J, Verstraete, K, Bloch, Y, Lorent, E, Wen, Y, Devreese, B, Vandenbroucke, K, Loverix, S, Hettmann, T, Deroo, S, Somers, K, Henderikx, P, Lasters, I, Savvides, S. | | Deposit date: | 2016-11-29 | | Release date: | 2017-01-11 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | STRUCTURAL BASIS OF IL-23 ANTAGONISM BY AN ALPHABODY PROTEIN
Nature Communications, 5, 2014
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8P8T
 | | Ex vivo Ym2 crystal structure | | Descriptor: | Chitinase-like protein 4, GLYCEROL | | Authors: | Verschueren, K.H.G, Verstraete, K, Heyndrickx, I, Smole, U, Aegerter, H, Savvides, S.N, Lambrecht, B.N. | | Deposit date: | 2023-06-02 | | Release date: | 2024-01-17 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Ym1 protein crystals promote type 2 immunity.
Elife, 12, 2024
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8P8Q
 | | Recombinant Ym1 crystal structure | | Descriptor: | ACETATE ION, Chitinase-like protein 3, GLYCEROL | | Authors: | Verschueren, K.H.G, Verstraete, K, Heyndrickx, I, Aegerter, H, Smole, U, Savvides, S.N, Lambrecht, B.N. | | Deposit date: | 2023-06-02 | | Release date: | 2024-01-17 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.792 Å) | | Cite: | Ym1 protein crystals promote type 2 immunity.
Elife, 12, 2024
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8P8S
 | | Recombinant Ym2 crystal structure | | Descriptor: | 1,2-ETHANEDIOL, Chitinase-like protein 4 | | Authors: | Verschueren, K.H.G, Verstraete, K, Heyndrickx, I, Smole, U, Aegerter, A, Savvides, S.N, Lambrecht, B.N. | | Deposit date: | 2023-06-02 | | Release date: | 2024-01-17 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.17 Å) | | Cite: | Ym1 protein crystals promote type 2 immunity.
Elife, 12, 2024
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8P8R
 | | Ex vivo Ym1 crystal structure | | Descriptor: | 1,2-ETHANEDIOL, Chitinase-like protein 3 | | Authors: | Verschueren, K.H.G, Verstraete, K, Heyndrickx, I, Smole, U, Aegerter, H, Savvides, S.N, Lambrecht, B.N. | | Deposit date: | 2023-06-02 | | Release date: | 2024-01-17 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Ym1 protein crystals promote type 2 immunity.
Elife, 12, 2024
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4C0R
 | | Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans. | | Descriptor: | CADMIUM ION, CHLORIDE ION, OXIDIZED GLUTATHIONE DISULFIDE, ... | | Authors: | Vergauwen, B, Verstraete, K, Senadheera, D.B, Dansercoer, A, Cvitkovitch, D.G, Guedon, E, Savvides, S.N. | | Deposit date: | 2013-08-07 | | Release date: | 2013-08-21 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.547 Å) | | Cite: | Molecular and Structural Basis of Glutathione Import in Gram-Positive Bacteria Via Gsht and the Cystine Abc Importer Tcybc of Streptococcus Mutans.
Mol.Microbiol., 89, 2013
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3UCE
 | | Crystal structure of a small-chain dehydrogenase in complex with NADPH | | Descriptor: | Dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Buysschaert, G, Verstraete, K, Savvides, S, Vergauwen, B. | | Deposit date: | 2011-10-26 | | Release date: | 2012-11-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference.
Febs J., 280, 2013
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3UCF
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