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PDB: 17 件
3U78
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BU of 3u78 by Molmil
E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase
分子名称: 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, ...
著者Upadhyay, A.K, Cheng, X.
登録日2011-10-13
公開日2012-01-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.689 Å)
主引用文献An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases.
J.Mol.Biol., 416, 2012
3KV5
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BU of 3kv5 by Molmil
Structure of KIAA1718, human Jumonji demethylase, in complex with N-oxalylglycine
分子名称: FE (II) ION, JmjC domain-containing histone demethylation protein 1D, N-OXALYLGLYCINE, ...
著者Horton, J.R, Upadhyay, A.K, Qi, H.H, Zhang, X, Shi, Y, Cheng, X.
登録日2009-11-29
公開日2009-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
Nat.Struct.Mol.Biol., 17, 2010
3KV9
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BU of 3kv9 by Molmil
Structure of KIAA1718 Jumonji domain
分子名称: FE (II) ION, JmjC domain-containing histone demethylation protein 1D, OXYGEN MOLECULE
著者Horton, J.R, Upadhyay, A.K, Qi, H.H, Zhang, X, Shi, Y, Cheng, X.
登録日2009-11-29
公開日2009-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
Nat.Struct.Mol.Biol., 17, 2010
3KV4
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BU of 3kv4 by Molmil
Structure of PHF8 in complex with histone H3
分子名称: 1,2-ETHANEDIOL, FE (II) ION, Histone H3-like, ...
著者Horton, J.R, Upadhyay, A.K, Qi, H.H, Zhang, X, Shi, Y, Cheng, X.
登録日2009-11-29
公開日2009-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
Nat.Struct.Mol.Biol., 17, 2010
3KVB
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BU of 3kvb by Molmil
Structure of KIAA1718 Jumonji domain in complex with N-oxalylglycine
分子名称: JmjC domain-containing histone demethylation protein 1D, N-OXALYLGLYCINE, NICKEL (II) ION, ...
著者Horton, J.R, Upadhyay, A.K, Qi, H.H, Zhang, X, Shi, Y, Cheng, X.
登録日2009-11-29
公開日2009-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
Nat.Struct.Mol.Biol., 17, 2010
3KVA
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BU of 3kva by Molmil
Structure of KIAA1718 Jumonji domain in complex with alpha-ketoglutarate
分子名称: 2-OXOGLUTARIC ACID, FE (II) ION, JmjC domain-containing histone demethylation protein 1D, ...
著者Horton, J.R, Upadhyay, A.K, Qi, H.H, Zhang, X, Shi, Y, Cheng, X.
登録日2009-11-29
公開日2009-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
Nat.Struct.Mol.Biol., 17, 2010
3KV6
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BU of 3kv6 by Molmil
Structure of KIAA1718, human Jumonji demethylase, in complex with alpha-ketoglutarate
分子名称: 2-OXOGLUTARIC ACID, FE (II) ION, JmjC domain-containing histone demethylation protein 1D, ...
著者Horton, J.R, Upadhyay, A.K, Qi, H.H, Zhang, X, Shi, Y, Cheng, X.
登録日2009-11-29
公開日2009-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
Nat.Struct.Mol.Biol., 17, 2010
5TFR
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BU of 5tfr by Molmil
Crystal structure of Zika Virus NS5 protein
分子名称: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION
著者Longenecker, K.L, Upadhyay, A.K.
登録日2016-09-26
公開日2016-10-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5VAR
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BU of 5var by Molmil
Crystal structure of KDM4A tandem TUDOR domain in complex with a tri-methyl lysine competitive inhibitor
分子名称: (1R,2S,3R,4S)-3-[(dimethylamino)methyl]-1-phenylbicyclo[2.2.1]heptan-2-ol, Lysine-specific demethylase 4A
著者Judge, R.A, Upadhyay, A.K.
登録日2017-03-27
公開日2018-03-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.
Bioorg. Med. Chem. Lett., 28, 2018
3OS5
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BU of 3os5 by Molmil
SET7/9-Dnmt1 K142me1 complex
分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Dnmt1, ...
著者Esteve, P.-O, Chang, Y, Samaranayake, M, Upadhyay, A.K, Horton, J.R, Feehery, G.R, Cheng, X, Pradhan, S.
登録日2010-09-08
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.
Nat.Struct.Mol.Biol., 18, 2011
5CPR
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BU of 5cpr by Molmil
The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
分子名称: 6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine, Histone-lysine N-methyltransferase SUV420H1, S-ADENOSYLMETHIONINE, ...
著者Jakob, C.G, Upadhyay, A.K, Sun, C.
登録日2015-07-21
公開日2017-01-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Nat. Chem. Biol., 13, 2017
3PU8
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BU of 3pu8 by Molmil
PHF2 Jumonji-NOG-Fe(II) complex
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ...
著者Horton, J.R, Upadhyay, A.K, Hashimoto, H, Zhang, X, Cheng, X.
登録日2010-12-03
公開日2011-01-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.943 Å)
主引用文献Structural basis for human PHF2 Jumonji domain interaction with metal ions.
J.Mol.Biol., 406, 2011
3PUS
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BU of 3pus by Molmil
PHF2 Jumonji-NOG-Ni(II)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, N-OXALYLGLYCINE, ...
著者Horton, J.R, Upadhyay, A.K, Hashimoto, H, Zhang, X, Cheng, X.
登録日2010-12-06
公開日2011-01-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Structural basis for human PHF2 Jumonji domain interaction with metal ions.
J.Mol.Biol., 406, 2011
3PU3
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BU of 3pu3 by Molmil
PHF2 Jumonji domain-NOG complex
分子名称: 1,2-ETHANEDIOL, GLYCEROL, N-OXALYLGLYCINE, ...
著者Horton, J.R, Upadhyay, A.K, Hashimoto, H, Zhang, X, Cheng, X.
登録日2010-12-03
公開日2011-01-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural basis for human PHF2 Jumonji domain interaction with metal ions.
J.Mol.Biol., 406, 2011
3PTR
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BU of 3ptr by Molmil
PHF2 Jumonji domain
分子名称: 1,2-ETHANEDIOL, PHD finger protein 2
著者Horton, J.R, Upadhyay, A.K, Hashimoto, H, Zhang, X, Cheng, X.
登録日2010-12-03
公開日2011-01-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.954 Å)
主引用文献Structural basis for human PHF2 Jumonji domain interaction with metal ions.
J.Mol.Biol., 406, 2011
3PUA
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BU of 3pua by Molmil
PHF2 Jumonji-NOG-Ni(II)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, N-OXALYLGLYCINE, ...
著者Horton, J.R, Upadhyay, A.K, Hashimoto, H, Zhang, X, Cheng, X.
登録日2010-12-03
公開日2011-01-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structural basis for human PHF2 Jumonji domain interaction with metal ions.
J.Mol.Biol., 406, 2011
3RDH
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BU of 3rdh by Molmil
X-ray induced covalent inhibition of 14-3-3
分子名称: 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION
著者Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X.
登録日2011-04-01
公開日2011-09-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor.
Proc.Natl.Acad.Sci.USA, 108, 2011

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件を2024-09-04に公開中

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