3U78
E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase
Summary for 3U78
Entry DOI | 10.2210/pdb3u78/pdb |
Related | 3KVA |
Descriptor | Lysine-specific demethylase 7, 2-OXOGLUTARIC ACID, NICKEL (II) ION, ... (8 entities in total) |
Functional Keywords | epigenetics, histone lysine demethylation, bix analogs, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q6ZMT4 |
Total number of polymer chains | 1 |
Total formula weight | 47091.24 |
Authors | Upadhyay, A.K.,Cheng, X. (deposition date: 2011-10-13, release date: 2012-01-25, Last modification date: 2023-09-13) |
Primary citation | Upadhyay, A.K.,Rotili, D.,Han, J.W.,Hu, R.,Chang, Y.,Labella, D.,Zhang, X.,Yoon, Y.S.,Mai, A.,Cheng, X. An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases. J.Mol.Biol., 416:319-327, 2012 Cited by PubMed: 22227394DOI: 10.1016/j.jmb.2011.12.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.689 Å) |
Structure validation
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