3U78
E67-2 selectively inhibits KIAA1718, a human histone H3 lysine 9 Jumonji demethylase
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE AKG A 701 |
| Chain | Residue |
| A | ASN224 |
| A | NI702 |
| A | E67707 |
| A | HOH801 |
| A | HOH843 |
| A | ILE226 |
| A | THR279 |
| A | HIS282 |
| A | ASP284 |
| A | TYR292 |
| A | LYS299 |
| A | HIS354 |
| A | VAL356 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 702 |
| Chain | Residue |
| A | HIS282 |
| A | ASP284 |
| A | HIS354 |
| A | AKG701 |
| A | HOH801 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 703 |
| Chain | Residue |
| A | SER249 |
| A | TRP250 |
| A | VAL251 |
| A | PHE369 |
| A | LEU370 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 704 |
| Chain | Residue |
| A | GLU309 |
| A | ARG313 |
| A | ASP333 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 705 |
| Chain | Residue |
| A | LYS153 |
| A | HOH873 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 706 |
| Chain | Residue |
| A | ASP167 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE E67 A 707 |
| Chain | Residue |
| A | GLN200 |
| A | ASP202 |
| A | LYS204 |
| A | ASP280 |
| A | ASP284 |
| A | PHE285 |
| A | PRO391 |
| A | ASP392 |
| A | AKG701 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 156 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20023638","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
