3BB8
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![BU of 3bb8 by Molmil](/molmil-images/mine/3bb8) | E1 Dehydrase H220K Mutant | 分子名称: | BENZAMIDINE, CDP-4-keto-6-deoxy-D-glucose-3-dehydrase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Tsai, S.-C, Smith, P. | 登録日 | 2007-11-09 | 公開日 | 2008-09-16 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | E1 Dehydrase H220K Mutant To be Published
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3BCX
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![BU of 3bcx by Molmil](/molmil-images/mine/3bcx) | E1 Dehydrase | 分子名称: | BENZAMIDINE, CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase, FE (III) ION | 著者 | Tsai, S.-C, Smith, P. | 登録日 | 2007-11-13 | 公開日 | 2007-11-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | E1 Dehydrase. To be Published
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1MNQ
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![BU of 1mnq by Molmil](/molmil-images/mine/1mnq) | Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.4 | 分子名称: | polyketide synthase IV | 著者 | Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M. | 登録日 | 2002-09-05 | 公開日 | 2003-02-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases Biochemistry, 41, 2002
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1MO2
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![BU of 1mo2 by Molmil](/molmil-images/mine/1mo2) | Thioesterase Domain from 6-Deoxyerythronolide Synthase (DEBS TE), pH 8.5 | 分子名称: | Erythronolide synthase, modules 5 and 6 | 著者 | Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M. | 登録日 | 2002-09-05 | 公開日 | 2003-02-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases Biochemistry, 41, 2002
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1MN6
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![BU of 1mn6 by Molmil](/molmil-images/mine/1mn6) | Thioesterase Domain from Picromycin Polyketide Synthase, pH 7.6 | 分子名称: | polyketide synthase IV | 著者 | Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M. | 登録日 | 2002-09-05 | 公開日 | 2003-02-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases Biochemistry, 41, 2002
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1MNA
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![BU of 1mna by Molmil](/molmil-images/mine/1mna) | Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0 | 分子名称: | polyketide synthase IV | 著者 | Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M. | 登録日 | 2002-09-05 | 公開日 | 2003-02-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases Biochemistry, 41, 2002
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4X4J
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![BU of 4x4j by Molmil](/molmil-images/mine/4x4j) | Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Putative oxygenase, SULFATE ION | 著者 | Tsai, S.-C, Jackson, D.R, Patel, A, Barajas, J.F, Rohr, J, Yu, X, Liu, H.-W, Sasaki, E, Calveras, J, Metsa-Ketela, M. | 登録日 | 2014-12-02 | 公開日 | 2015-12-02 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis To Be Published
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1KEZ
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![BU of 1kez by Molmil](/molmil-images/mine/1kez) | Crystal Structure of the Macrocycle-forming Thioesterase Domain of Erythromycin Polyketide Synthase (DEBS TE) | 分子名称: | ERYTHRONOLIDE SYNTHASE | 著者 | Tsai, S.-C, Miercke, L.J.W, Krucinski, J, Gokhale, R, Chen, J.C.-H, Foster, P.G, Cane, D.E, Khosla, C, Stroud, R.M. | 登録日 | 2001-11-19 | 公開日 | 2002-01-09 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proc.Natl.Acad.Sci.USA, 98, 2001
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4DC1
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![BU of 4dc1 by Molmil](/molmil-images/mine/4dc1) | |
4DC0
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![BU of 4dc0 by Molmil](/molmil-images/mine/4dc0) | |
4DBZ
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![BU of 4dbz by Molmil](/molmil-images/mine/4dbz) | |
3B6Z
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![BU of 3b6z by Molmil](/molmil-images/mine/3b6z) | Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA | 分子名称: | Enoyl reductase, GLYCEROL, S-{(9R,13R,15S)-17-[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl}(2E)-but-2-enethioate | 著者 | Ames, B.D, Smith, P.T, Ma, S.M, Wong, E.W, Xie, X, Vederas, J.C, Tang, Y, Tsai, S.-C. | 登録日 | 2007-10-29 | 公開日 | 2008-09-16 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proc.Natl.Acad.Sci.USA, 109, 2012
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3B70
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![BU of 3b70 by Molmil](/molmil-images/mine/3b70) | Crystal structure of Aspergillus terreus trans-acting lovastatin polyketide enoyl reductase (LovC) with bound NADP | 分子名称: | Enoyl reductase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Ames, B.D, Smith, P.T, Ma, S.M, Wong, E.W, Xie, X, Vederas, J.C, Tang, Y, Tsai, S.-C. | 登録日 | 2007-10-29 | 公開日 | 2008-09-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proc.Natl.Acad.Sci.USA, 109, 2012
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3QRW
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![BU of 3qrw by Molmil](/molmil-images/mine/3qrw) | |
3RI3
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![BU of 3ri3 by Molmil](/molmil-images/mine/3ri3) | |
1R2J
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![BU of 1r2j by Molmil](/molmil-images/mine/1r2j) | FkbI for Biosynthesis of Methoxymalonyl Extender Unit of Fk520 Polyketide Immunosuppresant | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, protein FkbI | 著者 | Watanabe, K, Khosla, C, Stroud, R.M, Tsai, S.-C. | 登録日 | 2003-09-28 | 公開日 | 2003-11-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of an Acyl-ACP Dehydrogenase from the FK520 Polyketide Biosynthetic Pathway: Insights into Extender Unit Biosynthesis J.Mol.Biol., 334, 2003
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3HF1
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![BU of 3hf1 by Molmil](/molmil-images/mine/3hf1) | Crystal structure of human p53R2 | 分子名称: | FE (III) ION, Ribonucleoside-diphosphate reductase subunit M2 B, SULFATE ION | 著者 | Smith, P, Zhou, B, Yuan, Y.-C, Su, L, Tsai, S.-C, Yen, Y. | 登録日 | 2009-05-10 | 公開日 | 2009-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | 2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase . Biochemistry, 48, 2009
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3SJU
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![BU of 3sju by Molmil](/molmil-images/mine/3sju) | Hedamycin Polyketide Ketoreductase bound to NADPH | 分子名称: | Keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Javidpour, P, Tsai, S.-C. | 登録日 | 2011-06-21 | 公開日 | 2011-09-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase (HedKR): Molecular Basis of Stereo- and Regiospecificities. Biochemistry, 50, 2011
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3TVR
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3TVQ
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![BU of 3tvq by Molmil](/molmil-images/mine/3tvq) | Crystal structure of TCM Aro/Cyc complexed with trans-dihidroquercetin | 分子名称: | (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN | 著者 | Ames, B.D, Lee, M.-Y, Tsai, S.-C. | 登録日 | 2011-09-20 | 公開日 | 2012-04-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI. Biochemistry, 51, 2012
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3TL1
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![BU of 3tl1 by Molmil](/molmil-images/mine/3tl1) | Crystal structure of the Streptomyces coelicolor WhiE ORFVI polyketide aromatase/cyclase | 分子名称: | 6,7,9-trihydroxy-3-methyl-1H-benzo[g]isochromen-1-one, GLYCEROL, Polyketide cyclase | 著者 | Lee, M.-Y, Ames, B.D, Zhang, W, Tang, Y, Tsai, S.-C. | 登録日 | 2011-08-29 | 公開日 | 2012-04-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI. Biochemistry, 51, 2012
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2RH4
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![BU of 2rh4 by Molmil](/molmil-images/mine/2rh4) | Actinorhodin ketoreductase, actKR, with NADPH and Inhibitor Emodin | 分子名称: | 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Korman, T.P, Tsai, S.-C. | 登録日 | 2007-10-05 | 公開日 | 2008-08-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase Biochemistry, 47, 2008
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2RHC
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![BU of 2rhc by Molmil](/molmil-images/mine/2rhc) | Actinorhodin ketordeuctase, actKR, with NADP+ and Inhibitor Emodin | 分子名称: | 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Korman, T.P, Tsai, S.-C. | 登録日 | 2007-10-08 | 公開日 | 2008-08-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase Biochemistry, 47, 2008
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2RHR
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![BU of 2rhr by Molmil](/molmil-images/mine/2rhr) | P94L actinorhodin ketordeuctase mutant, with NADPH and Inhibitor Emodin | 分子名称: | 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Korman, T.P, Tsai, S.-C. | 登録日 | 2007-10-09 | 公開日 | 2008-08-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase Biochemistry, 47, 2008
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3GQV
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![BU of 3gqv by Molmil](/molmil-images/mine/3gqv) | Lovastatin polyketide enoyl reductase (LovC) mutant K54S with bound NADP | 分子名称: | Enoyl reductase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Ames, B.D, Smith, P.T, Ma, S.M, Kaake, R, Wong, E.W, Wong, S.K, Xie, X, Li, J.W, Vederas, J.C, Tang, Y, Tsai, S.-C. | 登録日 | 2009-03-24 | 公開日 | 2009-04-07 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | biosynthesis of Lovastatin: Crystal structure and biochemical
studies of LOVC, A trans-acting polyketide enoyl reductase To be Published
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