3SJU

Hedamycin Polyketide Ketoreductase bound to NADPH

Summary for 3SJU

Entry DOI	10.2210/pdb3sju/pdb
Descriptor	Keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
Functional Keywords	short-chain dehydrogenase, reductase, oxidoreductase, rossmann fold, type ii polyketide ketoreductase
Biological source	Streptomyces griseoruber
Total number of polymer chains	2
Total formula weight	59409.66
Authors	Javidpour, P.,Tsai, S.-C. (deposition date: 2011-06-21, release date: 2011-09-07, Last modification date: 2024-02-28)
Primary citation	Javidpour, P.,Das, A.,Khosla, C.,Tsai, S.C. Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase (HedKR): Molecular Basis of Stereo- and Regiospecificities. Biochemistry, 50:7426-7439, 2011 Cited by PubMed: 21776967 DOI: 10.1021/bi2006866 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation