2RHR

P94L actinorhodin ketordeuctase mutant, with NADPH and Inhibitor Emodin

Summary for 2RHR

Entry DOI	10.2210/pdb2rhr/pdb
Related	1X7G 1X7H 2RH4 2RHC
Descriptor	Actinorhodin Polyketide Ketoreductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, ... (4 entities in total)
Functional Keywords	oxidoreductase, polyketide, actinorhodin, ketoreductase, combinatorial biosynthesis, short chain dehydrogenase/reductase
Biological source	Streptomyces coelicolor
Total number of polymer chains	2
Total formula weight	60267.32
Authors	Korman, T.P.,Tsai, S.-C. (deposition date: 2007-10-09, release date: 2008-08-19, Last modification date: 2023-08-30)
Primary citation	Korman, T.P.,Tan, Y.H.,Wong, J.,Luo, R.,Tsai, S.-C. Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase Biochemistry, 47:1837-1847, 2008 Cited by PubMed: 18205400 DOI: 10.1021/bi7016427 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation