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2RHR

P94L actinorhodin ketordeuctase mutant, with NADPH and Inhibitor Emodin

Functional Information from GO Data
ChainGOidnamespacecontents
A0008202biological_processsteroid metabolic process
A0016491molecular_functionoxidoreductase activity
A0017000biological_processantibiotic biosynthetic process
B0008202biological_processsteroid metabolic process
B0016491molecular_functionoxidoreductase activity
B0017000biological_processantibiotic biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NDP B 301
ChainResidue
BGLY13
BVAL64
BASN90
BALA91
BGLY92
BILE142
BALA143
BSER144
BTYR157
BLYS161
BPRO187
BTHR15
BGLY188
BVAL190
BTHR192
BPRO193
BMET194
BHOH348
BSER16
BILE18
BALA37
BARG38
BGLY39
BCYS62
BASP63

site_idAC2
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NDP A 301
ChainResidue
AGLY13
ATHR15
ASER16
AGLY17
AILE18
AALA37
AARG38
AGLY39
ACYS62
AASP63
AVAL64
AASN90
AGLY92
AILE142
AALA143
ATYR157
ALYS161
APRO187
APHE189
AVAL190
ATHR192
APRO193
AMET194
AEMO302
AHOH342
AHOH346
BARG51

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE EMO A 302
ChainResidue
ALEU94
ASER144
ATHR145
ATYR157
AGLY188
APHE189
AMET194
AVAL198
AILE217
AVAL221
ALEU258
ANDP301
AEMO303

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EMO A 303
ChainResidue
ASER144
ATHR145
AGLY146
AGLN149
AVAL151
ATYR157
AARG220
ALEU258
AEMO302

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. StggkqgvvhAapYSASKHGVvGFTkALG
ChainResidueDetails
BSER144-GLY172

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001
ChainResidueDetails
BTYR157
ATYR157

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:15458634, ECO:0000269|PubMed:15544323
ChainResidueDetails
BVAL11
BASP63
BLYS161
AVAL11
AASP63
ALYS161

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BSER144
ASER144

Catalytic Information from CSA
site_idCSA1
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ybv
ChainResidueDetails
BASN114
BLYS161
BSER144
BTYR157

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ybv
ChainResidueDetails
AASN114
ALYS161
ASER144
ATYR157

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ybv
ChainResidueDetails
BALA154
BLYS161

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ybv
ChainResidueDetails
AALA154
ALYS161

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ybv
ChainResidueDetails
BLYS161
BTYR157

site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ybv
ChainResidueDetails
ALYS161
ATYR157

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PDB entries from 2024-10-30

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