3TVQ

Crystal structure of TCM Aro/Cyc complexed with trans-dihidroquercetin

Summary for 3TVQ

• Entry DOI: 10.2210/pdb3tvq/pdb
• Related: 2RER
• Descriptor: Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN, (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE (3 entities in total)
• Functional Keywords: tetracenomycin, aromatase, cyclase, taxifolin, dihyroquercetin, helix-grip fold, multifunctional cyclase-dehydratase-3-o-methyl transferase, transferase
• Biological source: Streptomyces glaucescens
• Total number of polymer chains: 1
• Total formula weight: 19847.16

Authors

Ames, B.D.,Lee, M.-Y.,Tsai, S.-C. (deposition date: 2011-09-20, release date: 2012-04-04, Last modification date: 2023-09-13)

• Primary citation: Lee, M.Y.,Ames, B.D.,Tsai, S.C.; Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI.; Biochemistry, 51:3079-3091, 2012; PubMed: 22432862; DOI: 10.1021/bi201705q

Experimental method

X-RAY DIFFRACTION (1.67 Å)