3RI3
Actinorhodin Polyketide Ketoreductase Mutant P94L bound to NADPH and the Inhibitor Emodin
Summary for 3RI3
Entry DOI | 10.2210/pdb3ri3/pdb |
Descriptor | ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, ... (4 entities in total) |
Functional Keywords | actinorhodin, polyketide, ketoreductase, short-chain dehydrogenase/reductase, rossmann fold, type ii polyketide ketoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Streptomyces coelicolor |
Total number of polymer chains | 2 |
Total formula weight | 61532.60 |
Authors | Javidpour, P.,Tsai, S.-C. (deposition date: 2011-04-12, release date: 2011-06-29, Last modification date: 2023-09-13) |
Primary citation | Javidpour, P.,Korman, T.P.,Shakya, G.,Tsai, S.C. Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide Ketoreductase. Biochemistry, 50:4638-4649, 2011 Cited by PubMed: 21506596DOI: 10.1021/bi200335f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.292 Å) |
Structure validation
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