1TTW
| |
1K6Z
| Crystal Structure of the Yersinia Secretion Chaperone SycE | 分子名称: | IMIDAZOLE, Type III secretion chaperone SycE | 著者 | Evdokimov, A.G, Tropea, J.E, Routzahn, K.M, Waugh, D.S. | 登録日 | 2001-10-17 | 公開日 | 2001-10-31 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Three-dimensional structure of the type III secretion chaperone SycE from Yersinia pestis. Acta Crystallogr.,Sect.D, 58, 2002
|
|
2WGP
| Crystal structure of human dual specificity phosphatase 14 | 分子名称: | DUAL SPECIFICITY PROTEIN PHOSPHATASE 14, PHOSPHATE ION | 著者 | Lountos, G.T, Tropea, J.E, Cherry, S, Waugh, D.S. | 登録日 | 2009-04-22 | 公開日 | 2009-10-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Overproduction, Purification and Structure Determination of Human Dual-Specificity Phosphatase 14. Acta Crystallogr.,Sect.D, 65, 2009
|
|
4WOH
| Structure of of human dual-specificity phosphatase 22 (E24A/K28A/K30A/C88S) complexed with 4-nitrophenolphosphate | 分子名称: | 1,2-ETHANEDIOL, 4-NITROPHENYL PHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Lountos, G.T, Cherry, S, Tropea, J.E, Waugh, D.S. | 登録日 | 2014-10-15 | 公開日 | 2015-02-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate. Acta Crystallogr.,Sect.F, 71, 2015
|
|
4M2Z
| Crystal structure of RNASE III complexed with double-stranded RNA and CMP (TYPE II CLEAVAGE) | 分子名称: | CYTIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, RNA10, ... | 著者 | Gan, J, Liang, Y.-H, Shaw, G.X, Tropea, J.E, Waugh, D.S, Ji, X. | 登録日 | 2013-08-05 | 公開日 | 2013-12-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | RNase III: Genetics and Function; Structure and Mechanism. Annu. Rev. Genet., 47, 2013
|
|
4M30
| Crystal structure of RNASE III complexed with double-stranded RNA AND AMP (TYPE II CLEAVAGE) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... | 著者 | Gan, J, Liang, Y.-H, Shaw, G.X, Tropea, J.E, Waugh, D.S, Ji, X. | 登録日 | 2013-08-05 | 公開日 | 2013-12-11 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | RNase III: Genetics and Function; Structure and Mechanism. Annu. Rev. Genet., 47, 2013
|
|
6APX
| Crystal structure of human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the monobody YSX1 | 分子名称: | GLYCEROL, Maltose-binding periplasmic protein,Dual specificity protein phosphatase 1, Monobody YSX1, ... | 著者 | Gumpena, R, Lountos, G.T, Sreejith, R.K, Tropea, J.E, Cherry, S, Waugh, D.S. | 登録日 | 2017-08-18 | 公開日 | 2017-11-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.491 Å) | 主引用文献 | Crystal structure of the human dual specificity phosphatase 1 catalytic domain. Protein Sci., 27, 2018
|
|
7UFZ
| Crystal structure of TDP1 complexed with compound XZ768 | 分子名称: | (4-{[(4S)-2-phenylimidazo[1,2-a]pyridin-3-yl]amino}phenyl)phosphonic acid, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... | 著者 | Lountos, G.T, Zhao, X.Z, Wang, W, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. | 登録日 | 2022-03-23 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.559 Å) | 主引用文献 | Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1. Front Chem, 10, 2022
|
|
7UFY
| Crystal structure of TDP1 complexed with compound XZ766 | 分子名称: | 1,2-ETHANEDIOL, Tyrosyl-DNA phosphodiesterase 1, [(4-{[(4S)-2,7-diphenylimidazo[1,2-a]pyridin-3-yl]amino}phenyl)methyl]phosphonic acid | 著者 | Lountos, G.T, Zhao, X.Z, Wang, W, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. | 登録日 | 2022-03-23 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.584 Å) | 主引用文献 | Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1. Front Chem, 10, 2022
|
|
7UPZ
| Structural basis for cell type specific DNA binding of C/EBPbeta: the case of cell cycle inhibitor p15INK4b promoter | 分子名称: | CCAAT/enhancer-binding protein beta, DNA (5'-D(*AP*TP*TP*CP*TP*TP*AP*AP*GP*AP*AP*AP*GP*AP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*TP*CP*TP*TP*TP*CP*TP*TP*AP*AP*GP*AP*A)-3') | 著者 | Lountos, G.T, Cherry, S, Tropea, J.E, Wlodawer, A, Miller, M. | 登録日 | 2022-04-18 | 公開日 | 2022-11-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.487 Å) | 主引用文献 | Structural basis for cell type specific DNA binding of C/EBP beta : The case of cell cycle inhibitor p15INK4b promoter. J.Struct.Biol., 214, 2022
|
|
6MJ5
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ519 | 分子名称: | 1,2-ETHANEDIOL, 4-hydroxy-8-nitroquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-09-20 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | 主引用文献 | Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
|
|
6N0O
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ523 | 分子名称: | 1,2-ETHANEDIOL, 4-nitrobenzene-1,2-dicarboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-11-07 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.943 Å) | 主引用文献 | Crystal structure of Tdp1 catalytic domain To Be Published
|
|
6MYZ
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ520 | 分子名称: | 1,2-ETHANEDIOL, 4-oxo-8-phenyl-1,4-dihydroquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-11-02 | 公開日 | 2019-11-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.661 Å) | 主引用文献 | Structure of Tdp1 catalytic domain in complex with compound XZ520 To Be Published
|
|
6N19
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ578 | 分子名称: | 1,2-ETHANEDIOL, 4-[(4-carboxybutanoyl)amino]benzene-1,2-dicarboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-11-08 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
|
|
6MZ0
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ530 | 分子名称: | 1,2-ETHANEDIOL, 5-hydroxypyrazine-2,3-dicarboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-11-02 | 公開日 | 2019-11-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.969 Å) | 主引用文献 | Structure of Tdp1 catalytic domain in complex with compound XZ530 To Be Published
|
|
6N0R
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ572 | 分子名称: | 1,2-ETHANEDIOL, 4-(methylamino)benzene-1,2-dicarboxylic acid, DIMETHYL SULFOXIDE, ... | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-11-07 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.544 Å) | 主引用文献 | Crystal structure of Tdp1 catalytic domain To Be Published
|
|
6N17
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ577 | 分子名称: | 1,2-ETHANEDIOL, 4-[(3-carboxypropanoyl)amino]benzene-1,2-dicarboxylic acid, DIMETHYL SULFOXIDE, ... | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-11-08 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.639 Å) | 主引用文献 | Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
|
|
6N0D
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ575 | 分子名称: | 1,2-ETHANEDIOL, 4-fluorobenzene-1,2-dicarboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-11-07 | 公開日 | 2019-11-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.453 Å) | 主引用文献 | Crystal structure of Tdp1 catalytic domain in complex with compound XZ575 To Be Published
|
|
6N0N
| Crystal structure of Tdp1 catalytic domain in complex with compound XZ574 | 分子名称: | 1,2-ETHANEDIOL, 4-methylbenzene-1,2-dicarboxylic acid, DIMETHYL SULFOXIDE, ... | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. | 登録日 | 2018-11-07 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.477 Å) | 主引用文献 | Crystal structure of Tdp1 catalytic domain To Be Published
|
|
2EZ6
| Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing | 分子名称: | 28-MER, MAGNESIUM ION, Ribonuclease III | 著者 | Gan, J, Tropea, J.E, Austin, B.P, Court, D.L, Waugh, D.S, Ji, X. | 登録日 | 2005-11-10 | 公開日 | 2006-02-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III. Cell(Cambridge,Mass.), 124, 2006
|
|
4Y2E
| Crystal structure of the catalytic domain of human dual-specificity phosphatase 7 (C232S) | 分子名称: | Dual specificity protein phosphatase 7, PHOSPHATE ION | 著者 | Lountos, G.T, Austin, B.P, Tropea, J.E, Waugh, D.S. | 登録日 | 2015-02-09 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Structure of human dual-specificity phosphatase 7, a potential cancer drug target. Acta Crystallogr.,Sect.F, 71, 2015
|
|
1XL3
| Complex structure of Y.pestis virulence Factors YopN and TyeA | 分子名称: | Secretion control protein, protein type A | 著者 | Schubot, F.D, Jackson, M.W, Penrose, K.J, Cherry, S, Tropea, J.E, Plano, G.V, Waugh, D.S. | 登録日 | 2004-09-30 | 公開日 | 2005-03-22 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis. J.Mol.Biol., 346, 2005
|
|
1XKP
| Crystal structure of the virulence factor YopN in complex with its heterodimeric chaperone SycN-YscB | 分子名称: | Chaperone protein sycN, Chaperone protein yscB, putative membrane-bound Yop targeting protein YopN | 著者 | Schubot, F.D, Jackson, M.W, Penrose, K.J, Cherry, S, Tropea, J.E, Plano, G.V, Waugh, D.S. | 登録日 | 2004-09-29 | 公開日 | 2005-03-22 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis. J.Mol.Biol., 346, 2005
|
|
4A0E
| |
4AZ1
| Crystal structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease | 分子名称: | 1,2-ETHANEDIOL, FORMIC ACID, TYROSINE SPECIFIC PROTEIN PHOSPHATASE | 著者 | Lountos, G.T, Tropea, J.E, Waugh, D.S. | 登録日 | 2012-06-22 | 公開日 | 2012-11-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.181 Å) | 主引用文献 | Structure of the Trypanosoma Cruzi Protein Tyrosine Phosphatase Tcptp1, a Potential Therapeutic Target for Chagas' Disease. Mol.Biochem.Parasitol., 187, 2012
|
|