6MZ0

Crystal structure of Tdp1 catalytic domain in complex with compound XZ530

Summary for 6MZ0

• Entry DOI: 10.2210/pdb6mz0/pdb
• Descriptor: Tyrosyl-DNA phosphodiesterase 1, 5-hydroxypyrazine-2,3-dicarboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: fragment based drug design, anti-cancer drug design, dna binding protein, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 104745.02

Authors

Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. (deposition date: 2018-11-02, release date: 2019-11-06, Last modification date: 2023-10-11)

• Primary citation: Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S.; Structure of Tdp1 catalytic domain in complex with compound XZ530; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.969 Å)