6MZ0
Crystal structure of Tdp1 catalytic domain in complex with compound XZ530
Summary for 6MZ0
Entry DOI | 10.2210/pdb6mz0/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 1, 5-hydroxypyrazine-2,3-dicarboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | fragment based drug design, anti-cancer drug design, dna binding protein, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 104745.02 |
Authors | Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. (deposition date: 2018-11-02, release date: 2019-11-06, Last modification date: 2023-10-11) |
Primary citation | Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. Structure of Tdp1 catalytic domain in complex with compound XZ530 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.969 Å) |
Structure validation
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