6MZ0
Crystal structure of Tdp1 catalytic domain in complex with compound XZ530
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue K7A A 701 |
| Chain | Residue |
| A | HIS263 |
| A | HOH886 |
| A | HOH953 |
| A | HOH966 |
| A | HOH1047 |
| A | LYS265 |
| A | ASN283 |
| A | PRO461 |
| A | HIS493 |
| A | LYS495 |
| A | ASN516 |
| A | HOH813 |
| A | HOH837 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 702 |
| Chain | Residue |
| A | ILE355 |
| A | GLY356 |
| A | SER357 |
| A | THR513 |
| A | TRP522 |
| A | GLY540 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue K7A B 701 |
| Chain | Residue |
| B | HIS263 |
| B | LYS265 |
| B | ASN283 |
| B | SER399 |
| B | SER459 |
| B | PRO461 |
| B | HIS493 |
| B | LYS495 |
| B | ASN516 |
| B | HOH817 |
| B | HOH827 |
| B | HOH836 |
| B | HOH875 |
| B | HOH922 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 702 |
| Chain | Residue |
| B | ILE355 |
| B | GLY356 |
| B | SER357 |
| B | THR513 |
| B | TRP522 |
| B | GLY540 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Region: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15111055","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15111055","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
