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6MYZ

Crystal structure of Tdp1 catalytic domain in complex with compound XZ520

Summary for 6MYZ
Entry DOI10.2210/pdb6myz/pdb
DescriptorTyrosyl-DNA phosphodiesterase 1, 4-oxo-8-phenyl-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsfragment based drug design, anti-cancer drug design, dna binding protein, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight104828.28
Authors
Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. (deposition date: 2018-11-02, release date: 2019-11-06, Last modification date: 2023-10-11)
Primary citationLountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S.
Structure of Tdp1 catalytic domain in complex with compound XZ520
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.661 Å)
Structure validation

217705

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