6N0O
Crystal structure of Tdp1 catalytic domain in complex with compound XZ523
Summary for 6N0O
Entry DOI | 10.2210/pdb6n0o/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 1, 1,2-ETHANEDIOL, 4-nitrobenzene-1,2-dicarboxylic acid, ... (4 entities in total) |
Functional Keywords | fragment based drug design, anti-cancer drug design, dna binding protein, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 104923.20 |
Authors | Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. (deposition date: 2018-11-07, release date: 2019-11-13, Last modification date: 2023-10-11) |
Primary citation | Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Burke Jr., T.R.,Pommier, Y.,Waugh, D.S. Crystal structure of Tdp1 catalytic domain To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.943 Å) |
Structure validation
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