5FWA
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![BU of 5fwa by Molmil](/molmil-images/mine/5fwa) | Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with CP1 | Descriptor: | 1,2-ETHANEDIOL, 9-(6-carbamimidamido-5,6-dideoxy-beta-D-ribo-hexofuranosyl)-9H-purin-6-amine, CALCIUM ION, ... | Authors: | Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-02-16 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. FEBS J., 284, 2017
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4C04
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![BU of 4c04 by Molmil](/molmil-images/mine/4c04) | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with inhibitor | Descriptor: | PROTEIN ARGININE N-METHYLTRANSFERASE 6, SINEFUNGIN | Authors: | Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. | Deposit date: | 2013-07-31 | Release date: | 2014-07-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.576 Å) | Cite: | Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
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4C03
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![BU of 4c03 by Molmil](/molmil-images/mine/4c03) | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 reduced | Descriptor: | PROTEIN ARGININE N-METHYLTRANSFERASE 6, SINEFUNGIN | Authors: | Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. | Deposit date: | 2013-07-31 | Release date: | 2014-07-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
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4C07
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![BU of 4c07 by Molmil](/molmil-images/mine/4c07) | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CaCl2 at 1.5 Angstroms | Descriptor: | CALCIUM ION, PROTEIN ARGININE N-METHYLTRANSFERASE 6 | Authors: | Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. | Deposit date: | 2013-07-31 | Release date: | 2014-07-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.499 Å) | Cite: | Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
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4C05
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![BU of 4c05 by Molmil](/molmil-images/mine/4c05) | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with SAH | Descriptor: | PROTEIN ARGININE N-METHYLTRANSFERASE 6, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. | Deposit date: | 2013-07-31 | Release date: | 2014-07-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.195 Å) | Cite: | Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
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4C08
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![BU of 4c08 by Molmil](/molmil-images/mine/4c08) | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CaCl2 at 1.34 Angstroms | Descriptor: | CALCIUM ION, PENTAETHYLENE GLYCOL, PROTEIN ARGININE N-METHYLTRANSFERASE 6 | Authors: | Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. | Deposit date: | 2013-07-31 | Release date: | 2014-07-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.338 Å) | Cite: | Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
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4C06
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![BU of 4c06 by Molmil](/molmil-images/mine/4c06) | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with MgCl2 | Descriptor: | MAGNESIUM ION, PROTEIN ARGININE N-METHYLTRANSFERASE 6 | Authors: | Bonnefond, L, Cura, V, Troffer-Charlier, N, Mailliot, J, Wurtz, J.M, Cavarelli, J. | Deposit date: | 2013-07-31 | Release date: | 2014-07-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Functional Insights from High Resolution Structures of Mouse Protein Arginine Methyltransferase 6. J.Struct.Biol., 191, 2015
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4C4A
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![BU of 4c4a by Molmil](/molmil-images/mine/4c4a) | Crystal structure of mouse protein arginine methyltransferase 7 in complex with SAH | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, PROTEIN ARGININE N-METHYLTRANSFERASE 7, ... | Authors: | Cura, V, Troffer-Charlier, N, Bonnefond, L, Wurtz, J.M, Cavarelli, J. | Deposit date: | 2013-09-02 | Release date: | 2014-07-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Insight Into Arginine Methylation by the Mouse Protein Arginine Methyltransferase 7: A Zinc Finger Freezes the Mimic of the Dimeric State Into a Single Active Site. Acta Crystallogr.,Sect.D, 70, 2014
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5K8X
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![BU of 5k8x by Molmil](/molmil-images/mine/5k8x) | Crystal structure of mouse CARM1 in complex with inhibitor U3 | Descriptor: | 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ... | Authors: | Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-05-31 | Release date: | 2017-06-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.991 Å) | Cite: | Crystal structure of mouse CARM1 in complex with inhibitor U3 To Be Published
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5K8V
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![BU of 5k8v by Molmil](/molmil-images/mine/5k8v) | Crystal Structure of Mus musculus Protein Arginine Methyltransferase 4 (CARM1 130-487) with CP1 | Descriptor: | 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, ... | Authors: | Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-05-31 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. FEBS J., 284, 2017
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5LV5
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![BU of 5lv5 by Molmil](/molmil-images/mine/5lv5) | Crystal structure of mouse PRMT6 in complex with inhibitor LH1458 | Descriptor: | 2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]-[(3~{S})-3-azanyl-4-oxidanyl-4-oxidanylidene-butyl]azanium, Protein arginine N-methyltransferase 6 | Authors: | Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-09-12 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373, 2018
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5LGS
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![BU of 5lgs by Molmil](/molmil-images/mine/5lgs) | Crystal structure of mouse CARM1 in complex with ligand P2C3u | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, ... | Authors: | Marechal, N, Troffer-Charlier, N, Cura, V, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-07-08 | Release date: | 2017-03-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5LGR
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![BU of 5lgr by Molmil](/molmil-images/mine/5lgr) | Crystal structure of mouse CARM1 in complex with ligand P1C3u | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, ... | Authors: | Marechal, N, Troffer-Charlier, N, Cura, V, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-07-08 | Release date: | 2017-03-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5LV2
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![BU of 5lv2 by Molmil](/molmil-images/mine/5lv2) | Crystal structure of mouse CARM1 in complex with inhibitor LH1246 | Descriptor: | 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ... | Authors: | Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-09-12 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos.Trans.R.Soc.Lond.B Biol.Sci., 373, 2018
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5LV4
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![BU of 5lv4 by Molmil](/molmil-images/mine/5lv4) | Crystal structure of mouse PRMT6 in complex with inhibitor LH1236 | Descriptor: | (2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid, Protein arginine N-methyltransferase 6 | Authors: | Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-09-12 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373, 2018
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5LKJ
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![BU of 5lkj by Molmil](/molmil-images/mine/5lkj) | Crystal structure of mouse CARM1 in complex with ligand SA684 | Descriptor: | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(2-carbamimidamidoethyl)amino]-2-azanyl-butanoic acid, 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, ... | Authors: | Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-07-22 | Release date: | 2017-08-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.595 Å) | Cite: | Crystal structure of mouse CARM1 in complex with ligands To Be Published
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5LV3
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![BU of 5lv3 by Molmil](/molmil-images/mine/5lv3) | Crystal structure of mouse CARM1 in complex with ligand LH1561Br | Descriptor: | 5-[[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]methyl]-4-azanyl-1-[2-(4-bromanylphenoxy)ethyl]pyrimidin-2-one, Histone-arginine methyltransferase CARM1, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-09-12 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373, 2018
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5LGQ
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![BU of 5lgq by Molmil](/molmil-images/mine/5lgq) | Crystal structure of mouse CARM1 in complex with ligand P2C3s | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-propyl-oxolane-3,4-diol, 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, ... | Authors: | Marechal, N, Troffer-Charlier, N, Cura, V, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-07-08 | Release date: | 2017-03-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5LGP
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![BU of 5lgp by Molmil](/molmil-images/mine/5lgp) | Crystal structure of mouse CARM1 in complex with ligand P1C3s | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-propyl-oxolane-3,4-diol, 1,2-ETHANEDIOL, Histone-arginine methyltransferase CARM1, ... | Authors: | Marechal, N, Troffer-Charlier, N, Cura, V, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-07-08 | Release date: | 2017-03-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5IS8
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![BU of 5is8 by Molmil](/molmil-images/mine/5is8) | Crystal structure of mouse CARM1 in complex with inhibitor SA0271 | Descriptor: | 1,2-ETHANEDIOL, 5'-{[(3S)-3-amino-3-carboxypropyl](2-chloroethyl)amino}-5'-deoxyadenosine, Histone-arginine methyltransferase CARM1, ... | Authors: | Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-03-15 | Release date: | 2017-03-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.709 Å) | Cite: | Crystal structure of mouse CARM1 in complex with inhibitor SA0271 To Be Published
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5ISH
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![BU of 5ish by Molmil](/molmil-images/mine/5ish) | Crystal structure of mouse CARM1 in complex with inhibitor SA0765 | Descriptor: | 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ... | Authors: | Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-03-15 | Release date: | 2017-03-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.152 Å) | Cite: | Crystal structure of mouse CARM1 in complex with inhibitor SA0765 To Be Published
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5IS7
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![BU of 5is7 by Molmil](/molmil-images/mine/5is7) | Crystal structure of mouse CARM1 in complex with decarboxylated SAH | Descriptor: | 1,2-ETHANEDIOL, 5'-S-(3-aminopropyl)-5'-thioadenosine, DI(HYDROXYETHYL)ETHER, ... | Authors: | Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-03-15 | Release date: | 2017-03-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Crystal structure of mouse CARM1 in complex with decarboxylated SAH To Be Published
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5ISI
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![BU of 5isi by Molmil](/molmil-images/mine/5isi) | Crystal structure of mouse CARM1 in complex with inhibitor SA0920 (5'-amino-5'-deoxyadenosine) | Descriptor: | 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 5'-amino-5'-deoxyadenosine, ... | Authors: | Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-03-15 | Release date: | 2017-03-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Crystal structure of mouse CARM1 in complex with inhibitor SA0920 (5'-amino-5'-deoxyadenosine) To Be Published
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5ISC
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![BU of 5isc by Molmil](/molmil-images/mine/5isc) | Crystal structure of mouse CARM1 in complex with inhibitor SA0491 | Descriptor: | 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE, ... | Authors: | Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-03-15 | Release date: | 2017-03-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of mouse CARM1 in complex with inhibitor SA0491 To Be Published
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5IH3
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![BU of 5ih3 by Molmil](/molmil-images/mine/5ih3) | Crystal structure of mouse CARM1 in complex with SAH at 1.8 Angstroms resolution | Descriptor: | 1,2-DIMETHOXYETHANE, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ... | Authors: | Cura, V, Marechal, N, Mailliot, J, Troffer-Charlier, N, Hassenboehler, P, Wurtz, J.M, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-02-29 | Release date: | 2017-03-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal structure of mouse CARM1 in complex with SAH at 1.8 Angstroms resolution To Be Published
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