5ISC

Crystal structure of mouse CARM1 in complex with inhibitor SA0491

Summary for 5ISC

DescriptorHistone-arginine methyltransferase CARM1, 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywordsprotein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
Biological sourceMus musculus (Mouse)
Cellular locationNucleus Q9WVG6
Total number of polymer chains4
Total molecular weight165864.13
Authors
Primary citation
Cura, V.,Marechal, N.,Mailliot, J.,Troffer-Charlier, N.,Wurtz, J.M.,Bonnefond, L.,Cavarelli, J.
Crystal structure of mouse CARM1 in complex with inhibitor SA0491
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.240200.6%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution