5LV3

Crystal structure of mouse CARM1 in complex with ligand LH1561Br

Summary for 5LV3

• Entry DOI: 10.2210/pdb5lv3/pdb
• Descriptor: Histone-arginine methyltransferase CARM1, S-ADENOSYL-L-HOMOCYSTEINE, 5-[[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]methyl]-4-azanyl-1-[2-(4-bromanylphenoxy)ethyl]pyrimidin-2-one, ... (4 entities in total)
• Functional Keywords: protein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
• Biological source: Mus musculus (House Mouse)
• Cellular location: Nucleus: Q9WVG6
• Total number of polymer chains: 4
• Total formula weight: 165375.53

Authors

Cura, V.,Marechal, N.,Troffer-Charlier, N.,Halby, L.,Arimondo, P.,Bonnefond, L.,Cavarelli, J. (deposition date: 2016-09-12, release date: 2017-09-20, Last modification date: 2024-01-17)

• Primary citation: Halby, L.,Marechal, N.,Pechalrieu, D.,Cura, V.,Franchini, D.M.,Faux, C.,Alby, F.,Troffer-Charlier, N.,Kudithipudi, S.,Jeltsch, A.,Aouadi, W.,Decroly, E.,Guillemot, J.C.,Page, P.,Ferroud, C.,Bonnefond, L.,Guianvarc'h, D.,Cavarelli, J.,Arimondo, P.B.; Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.; Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373:-, 2018; PubMed: 29685976; DOI: 10.1098/rstb.2017.0072

Experimental method

X-RAY DIFFRACTION (1.8 Å)