5LV3

Crystal structure of mouse CARM1 in complex with ligand LH1561Br

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Histone-arginine methyltransferase CARM1	polymer	361	40850.5	4	UniProt (Q9WVG6) Pfam (PF06325) Pfam (PF22528)	Mus musculus (House Mouse)	Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4
2	E, H (A, D)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) PubChem (177678424) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (6419189) PubChem (193) PubChem (164157219) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890)
3	F, G (B, C)	5-[[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]methyl]-4-azanyl-1-[2-(4-bromanylphenoxy)ethyl]pyrimidin-2-one	non-polymer		602.4	2	Chemie (LHF) PubChem (132229057) PubChem (129900306)
4	I, J, K, L (A, B, C, D)	water	water		18.0	1126	Chemie (HOH)

Sequence modifications

A, B, C, D: 130 - 487 (UniProt: Q9WVG6)

PDB	External Database	Details
Gly 127	-	expression tag
His 128	-	expression tag
Met 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	163401.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1973.7
All*	Total formula weight	165375.5

*Water molecules are not included.