1QYS
| Crystal structure of Top7: A computationally designed protein with a novel fold | Descriptor: | TOP7 | Authors: | Kuhlman, B, Dantas, G, Ireton, G.C, Varani, G, Stoddard, B.L, Baker, D. | Deposit date: | 2003-09-11 | Release date: | 2003-11-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Design of a Novel Globular Protein Fold with Atomic-Level Accuracy Science, 302, 2003
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1B0A
| 5,10, METHYLENE-TETRAHYDROPHOLATE DEHYDROGENASE/CYCLOHYDROLASE FROM E COLI. | Descriptor: | PROTEIN (FOLD BIFUNCTIONAL PROTEIN) | Authors: | Shen, B.W, Dyer, D, Huang, J.-Y, D'Ari, L, Rabinowitz, J, Stoddard, B.L. | Deposit date: | 1998-11-06 | Release date: | 1999-06-29 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase. Protein Sci., 8, 1999
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1RB7
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1OX7
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1D7P
| Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A | Descriptor: | COAGULATION FACTOR VIII PRECURSOR, CYSTEINE, GLYCEROL, ... | Authors: | Pratt, K.P, Shen, B.W, Stoddard, B.L. | Deposit date: | 1999-10-19 | Release date: | 1999-12-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of the C2 domain of human factor VIII at 1.5 A resolution. Nature, 402, 1999
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3O6Y
| Robust computational design, optimization, and structural characterization of retroaldol enzymes | Descriptor: | Retro-Aldolase, SULFATE ION | Authors: | Althoff, E.A, Wang, L, Jiang, L, Moody, J, Bolduc, J, Lassila, J.K, Wang, Z.Z, Smith, M, Hari, S, Herschlag, D, Stoddard, B.L, Baker, D. | Deposit date: | 2010-07-29 | Release date: | 2011-06-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.091 Å) | Cite: | Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J.Mol.Biol., 415, 2012
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8FLX
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1A3X
| PYRUVATE KINASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH PG, MN2+ AND K+ | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, POTASSIUM ION, ... | Authors: | Jurica, M.S, Mesecar, A, Heath, P.J, Shi, W, Nowak, T, Stoddard, B.L. | Deposit date: | 1998-01-26 | Release date: | 1998-05-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Structure, 6, 1998
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3R3P
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1A3W
| PYRUVATE KINASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH FBP, PG, MN2+ AND K+ | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, ... | Authors: | Jurica, M.S, Mesecar, A, Heath, P.J, Shi, W, Nowak, T, Stoddard, B.L. | Deposit date: | 1998-01-26 | Release date: | 1998-05-27 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Structure, 6, 1998
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1DT0
| CLONING, SEQUENCE, AND CRYSTALLOGRAPHIC STRUCTURE OF RECOMBINANT IRON SUPEROXIDE DISMUTASE FROM PSEUDOMONAS OVALIS | Descriptor: | FE (III) ION, SUPEROXIDE DISMUTASE | Authors: | Bond, C.J, Huang, J, Hajduk, R, Flick, K, Heath, P, Stoddard, B.L. | Deposit date: | 2000-01-10 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Cloning, sequence and crystallographic structure of recombinant iron superoxide dismutase from Pseudomonas ovalis. Acta Crystallogr.,Sect.D, 56, 2000
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1IDC
| ISOCITRATE DEHYDROGENASE FROM E.COLI (MUTANT K230M), STEADY-STATE INTERMEDIATE COMPLEX DETERMINED BY LAUE CRYSTALLOGRAPHY | Descriptor: | 2-OXALOSUCCINIC ACID, ISOCITRATE DEHYDROGENASE, MAGNESIUM ION | Authors: | Bolduc, J.M, Dyer, D.H, Scott, W.G, Singer, P, Sweet, R.M, Koshland Junior, D.E, Stoddard, B.L. | Deposit date: | 1995-01-18 | Release date: | 1996-03-08 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase. Science, 268, 1995
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5CW9
| Crystal structure of De novo designed ferredoxin-ferredoxin domain insertion protein | Descriptor: | De novo designed ferredoxin-ferredoxin domain insertion protein | Authors: | DiMaio, F, King, I.C, Gleixner, J, Doyle, L, Stoddard, B, Baker, D. | Deposit date: | 2015-07-28 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.108 Å) | Cite: | Precise assembly of complex beta sheet topologies from de novo designed building blocks. Elife, 4, 2015
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1IDE
| ISOCITRATE DEHYDROGENASE Y160F MUTANT STEADY-STATE INTERMEDIATE COMPLEX (LAUE DETERMINATION) | Descriptor: | ISOCITRATE DEHYDROGENASE, ISOCITRIC ACID, MAGNESIUM ION, ... | Authors: | Bolduc, J.M, Dyer, D.H, Scott, W.G, Singer, P, Sweet, R.M, Koshland Junior, D.E, Stoddard, B.L. | Deposit date: | 1995-01-18 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase. Science, 268, 1995
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1BP7
| GROUP I MOBILE INTRON ENDONUCLEASE I-CREI COMPLEXED WITH HOMING SITE DNA | Descriptor: | CALCIUM ION, DNA (5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP* GP*C)-3'), DNA (5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP* CP*G)-3'), ... | Authors: | Jurica, M.S, Monnat Junior, R.J, Stoddard, B.L. | Deposit date: | 1998-08-13 | Release date: | 1999-01-06 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI. Mol.Cell, 2, 1998
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1AF5
| GROUP I MOBILE INTRON ENDONUCLEASE | Descriptor: | I-CREI | Authors: | Heath, P.J, Stephens, K.M, Monnat Junior, R.J, Stoddard, B.L. | Deposit date: | 1997-03-21 | Release date: | 1997-07-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structure of I-Crel, a group I intron-encoded homing endonuclease. Nat.Struct.Biol., 4, 1997
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4YXX
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4YXZ
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1R9Y
| Bacterial cytosine deaminase D314A mutant. | Descriptor: | Cytosine deaminase, FE (III) ION, GLYCEROL, ... | Authors: | Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E. | Deposit date: | 2003-10-31 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng.Des.Sel., 17, 2004
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1RC8
| T4 Polynucleotide Kinase bound to 5'-GTCAC-3' ssDNA | Descriptor: | 5'-D(*GP*TP*CP*AP*C)-3', ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Eastberg, J.H, Pelletier, J, Stoddard, B.L. | Deposit date: | 2003-11-03 | Release date: | 2004-02-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase. Nucleic Acids Res., 32, 2004
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1R9Z
| Bacterial cytosine deaminase D314S mutant. | Descriptor: | Cytosine deaminase, FE (III) ION, GLYCEROL, ... | Authors: | Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E. | Deposit date: | 2003-10-31 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng.Des.Sel., 17, 2004
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1RA5
| Bacterial cytosine deaminase D314A mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine. | Descriptor: | (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, Cytosine deaminase, FE (III) ION, ... | Authors: | Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E. | Deposit date: | 2003-10-31 | Release date: | 2004-10-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng.Des.Sel., 17, 2004
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1RPZ
| T4 POLYNUCLEOTIDE KINASE BOUND TO 5'-TGCAC-3' SSDNA | Descriptor: | 5'-D(*TP*GP*CP*AP*C)-3', ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Eastberg, J.H, Pelletier, J, Stoddard, B.L. | Deposit date: | 2003-12-03 | Release date: | 2004-02-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase. Nucleic Acids Res., 32, 2004
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1R9X
| Bacterial cytosine deaminase D314G mutant. | Descriptor: | Cytosine deaminase, FE (III) ION, GLYCEROL, ... | Authors: | Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E. | Deposit date: | 2003-10-31 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng.Des.Sel., 17, 2004
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1RA0
| Bacterial cytosine deaminase D314G mutant bound to 5-fluoro-4-(S)-hydroxy-3,4-dihydropyrimidine. | Descriptor: | (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, Cytosine deaminase, FE (III) ION | Authors: | Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E. | Deposit date: | 2003-10-31 | Release date: | 2004-10-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng.Des.Sel., 17, 2004
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