1RA5
Bacterial cytosine deaminase D314A mutant bound to 5-fluoro-4-(S)-hydroxyl-3,4-dihydropyrimidine.
Summary for 1RA5
Entry DOI | 10.2210/pdb1ra5/pdb |
Related | 1K7O 1R9X 1R9Y 1R9Z 1RA0 1RAK 1RB7 |
Descriptor | Cytosine deaminase, FE (III) ION, (4S)-5-FLUORO-4-HYDROXY-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE, ... (5 entities in total) |
Functional Keywords | cytosine deaminase, alpha-beta barrel, hexamer, conformational change, d314a mutant, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 48096.02 |
Authors | Mahan, S.D.,Ireton, G.C.,Stoddard, B.L.,Black, M.E. (deposition date: 2003-10-31, release date: 2004-10-05, Last modification date: 2024-04-03) |
Primary citation | Mahan, S.D.,Ireton, G.C.,Knoeber, C.,Stoddard, B.L.,Black, M.E. Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng.Des.Sel., 17:625-633, 2004 Cited by PubMed: 15381761DOI: 10.1093/protein/gzh074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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