8SVF
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![BU of 8svf by Molmil](/molmil-images/mine/8svf) | BAP1/ASXL1 bound to the H2AK119Ub Nucleosome | Descriptor: | DNA/RNA (187-MER), DNA/RNA (327-MER), Histone H2A type 1, ... | Authors: | Thomas, J.F, Valencia-Sanchez, M.I, Armache, K.-J. | Deposit date: | 2023-05-16 | Release date: | 2023-08-30 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1. Sci Adv, 9, 2023
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3ZNG
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![BU of 3zng by Molmil](/molmil-images/mine/3zng) | Ankyrin repeat and SOCS-box protein 9 (ASB9) in complex with ElonginB and ElonginC | Descriptor: | 1,2-ETHANEDIOL, ANKYRIN REPEAT AND SOCS BOX PROTEIN 9, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... | Authors: | Thomas, J, Van Molle, I, Ciulli, A. | Deposit date: | 2013-02-14 | Release date: | 2013-12-04 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Multimeric Complexes Among Ankyrin-Repeat and Socs-Box Protein 9 (Asb9), Elonginbc, and Cullin 5: Insights Into the Structure and Assembly of Ecs-Type Cullin-Ring E3 Ubiquitin Ligases. Biochemistry, 52, 2013
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5UM1
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![BU of 5um1 by Molmil](/molmil-images/mine/5um1) | XFEL structure of influenza A M2 wild type TM domain at intermediate pH in the lipidic cubic phase at room temperature | Descriptor: | CALCIUM ION, CHLORIDE ION, Matrix protein 2 | Authors: | Thomaston, J.L, Woldeyes, R.A, Fraser, J.S, DeGrado, W.F. | Deposit date: | 2017-01-25 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.451 Å) | Cite: | XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6US8
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6US9
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6NV1
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![BU of 6nv1 by Molmil](/molmil-images/mine/6nv1) | Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor | Descriptor: | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHLORIDE ION, ... | Authors: | Thomaston, J.L, Liu, L, DeGrado, W.F. | Deposit date: | 2019-02-04 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry, 59, 2020
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6OUG
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![BU of 6oug by Molmil](/molmil-images/mine/6oug) | Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct | Descriptor: | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, Matrix protein 2 | Authors: | Thomaston, J.L, Liu, L, DeGrado, W.F. | Deposit date: | 2019-05-04 | Release date: | 2020-01-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry, 59, 2020
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5JOO
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![BU of 5joo by Molmil](/molmil-images/mine/5joo) | XFEL structure of influenza A M2 wild type TM domain at low pH in the lipidic cubic phase at room temperature | Descriptor: | CALCIUM ION, CHLORIDE ION, Matrix protein 2 | Authors: | Thomaston, J.L, Woldeyes, R.A, Fraser, J.S, DeGrado, W.F. | Deposit date: | 2016-05-02 | Release date: | 2017-08-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.413 Å) | Cite: | XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6MJH
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5TTC
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![BU of 5ttc by Molmil](/molmil-images/mine/5ttc) | XFEL structure of influenza A M2 wild type TM domain at high pH in the lipidic cubic phase at room temperature | Descriptor: | CALCIUM ION, CHLORIDE ION, Matrix protein 2 | Authors: | Thomaston, J.L, Woldeyes, R.A, Fraser, J.S, DeGrado, W.F. | Deposit date: | 2016-11-02 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6BMZ
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![BU of 6bmz by Molmil](/molmil-images/mine/6bmz) | Influenza A M2 transmembrane domain bound to a spiroadamantane inhibitor | Descriptor: | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, CHLORIDE ION, Matrix protein 2 | Authors: | Thomaston, J.L, DeGrado, W.F. | Deposit date: | 2017-11-15 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.634 Å) | Cite: | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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6BKL
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![BU of 6bkl by Molmil](/molmil-images/mine/6bkl) | Influenza A M2 transmembrane domain bound to rimantadine | Descriptor: | (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, Matrix protein 2, RIMANTADINE | Authors: | Thomaston, J.L, DeGrado, W.F. | Deposit date: | 2017-11-08 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.995 Å) | Cite: | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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6BKK
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![BU of 6bkk by Molmil](/molmil-images/mine/6bkk) | Influenza A M2 transmembrane domain bound to amantadine | Descriptor: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, CHLORIDE ION, Matrix protein 2 | Authors: | Thomaston, J.L, DeGrado, W.F. | Deposit date: | 2017-11-08 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.995 Å) | Cite: | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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6BOC
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![BU of 6boc by Molmil](/molmil-images/mine/6boc) | Influenza A M2 transmembrane domain bound to rimantadine in the Inward(open) conformation | Descriptor: | (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, CHLORIDE ION, Matrix protein 2, ... | Authors: | Thomaston, J.L, DeGrado, W.F. | Deposit date: | 2017-11-19 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140, 2018
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4QK7
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4QKC
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![BU of 4qkc by Molmil](/molmil-images/mine/4qkc) | Influenza A M2 wild type TM domain at low pH in the lipidic cubic phase under cryo diffraction conditions | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Thomaston, J.L, DeGrado, W.F. | Deposit date: | 2014-06-05 | Release date: | 2015-11-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction. Proc.Natl.Acad.Sci.USA, 112, 2015
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4QKM
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![BU of 4qkm by Molmil](/molmil-images/mine/4qkm) | Influenza A M2 wild type TM domain at low pH in the lipidic cubic phase under room temperature diffraction conditions | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Thomaston, J.L, DeGrado, W.F. | Deposit date: | 2014-06-06 | Release date: | 2015-11-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction. Proc.Natl.Acad.Sci.USA, 112, 2015
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4QKL
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5C02
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6HYT
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![BU of 6hyt by Molmil](/molmil-images/mine/6hyt) | Crystal structure of DHX8 helicase domain bound to ADP at 2.3 Angstrom | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Felisberto-Rodrigues, C, Thomas, J.C, McAndrew, P.C, Le Bihan, Y.V, Burke, R, Workman, P, van Montfort, R.L.M. | Deposit date: | 2018-10-22 | Release date: | 2019-08-28 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. Biochem.J., 476, 2019
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6HYS
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![BU of 6hys by Molmil](/molmil-images/mine/6hys) | Crystal structure of DHX8 helicase domain bound to ADP at 2.6 angstrom | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Felisberto-Rodrigues, C, Thomas, J.C, McAndrew, P.C, Le Bihan, Y.V, Burke, R, Workman, P, van Montfort, R.L.M. | Deposit date: | 2018-10-22 | Release date: | 2019-08-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. Biochem.J., 476, 2019
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6HYU
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![BU of 6hyu by Molmil](/molmil-images/mine/6hyu) | Crystal structure of DHX8 helicase bound to single stranded poly-adenine RNA | Descriptor: | 1,2-ETHANEDIOL, ATP-dependent RNA helicase DHX8, RNA (5'-R(*A*AP*A)-3'), ... | Authors: | Felisberto-Rodrigues, C, Thomas, J.C, McAndrew, P.C, Le Bihan, Y.V, Burke, R, Workman, P, van Montfort, R.L.M. | Deposit date: | 2018-10-22 | Release date: | 2019-08-28 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. Biochem.J., 476, 2019
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1YQA
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4N5B
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![BU of 4n5b by Molmil](/molmil-images/mine/4n5b) | Crystal structure of the Nipah virus phosphoprotein tetramerization domain | Descriptor: | IMIDAZOLE, Phosphoprotein | Authors: | Bruhn, J.F, Barnett, K, Bibby, J, Thomas, J, Keegan, R, Rigden, D, Bornholdt, Z.A, Saphire, E.O. | Deposit date: | 2013-10-09 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the nipah virus phosphoprotein tetramerization domain. J.Virol., 88, 2014
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1AAB
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![BU of 1aab by Molmil](/molmil-images/mine/1aab) | NMR STRUCTURE OF RAT HMG1 HMGA FRAGMENT | Descriptor: | HIGH MOBILITY GROUP PROTEIN | Authors: | Hardman, C.H, Broadhurst, R.W, Raine, A.R.C, Grasser, K.D, Thomas, J.O, Laue, E.D. | Deposit date: | 1995-10-28 | Release date: | 1996-03-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three- and four-dimensional NMR spectroscopy. Biochemistry, 34, 1995
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