6BOC
Influenza A M2 transmembrane domain bound to rimantadine in the Inward(open) conformation
Summary for 6BOC
| Entry DOI | 10.2210/pdb6boc/pdb |
| Descriptor | Matrix protein 2, CHLORIDE ION, (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, ... (6 entities in total) |
| Functional Keywords | influenza m2, proton channel, membrane protein, rimantadine |
| Biological source | Influenza A virus |
| Total number of polymer chains | 4 |
| Total formula weight | 11434.41 |
| Authors | Thomaston, J.L.,DeGrado, W.F. (deposition date: 2017-11-19, release date: 2018-09-19, Last modification date: 2023-10-04) |
| Primary citation | Thomaston, J.L.,Polizzi, N.F.,Konstantinidi, A.,Wang, J.,Kolocouris, A.,DeGrado, W.F. Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140:15219-15226, 2018 Cited by PubMed: 30165017DOI: 10.1021/jacs.8b06741 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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