6BOC
Influenza A M2 transmembrane domain bound to rimantadine in the Inward(open) conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0055036 | cellular_component | virion membrane |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0015078 | molecular_function | proton transmembrane transporter activity |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0055036 | cellular_component | virion membrane |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0015078 | molecular_function | proton transmembrane transporter activity |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0055036 | cellular_component | virion membrane |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0015078 | molecular_function | proton transmembrane transporter activity |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0055036 | cellular_component | virion membrane |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue CL A 101 |
| Chain | Residue |
| A | SER23 |
| B | SER22 |
| B | SER23 |
| C | SER22 |
| C | SER23 |
| C | NA102 |
| D | SER23 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EU7 A 102 |
| Chain | Residue |
| C | SER31 |
| C | RIM101 |
| C | HOH201 |
| D | SER31 |
| D | HOH102 |
| A | SER31 |
| C | ALA30 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue RIM C 101 |
| Chain | Residue |
| A | SER31 |
| A | EU7102 |
| B | HOH102 |
| C | ALA30 |
| C | SER31 |
| C | HOH201 |
| D | SER31 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 102 |
| Chain | Residue |
| A | SER22 |
| A | CL101 |
| A | HOH202 |
| B | SER22 |
| C | SER22 |
| D | SER22 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide ACE B 21 and SER B 22 |
| Chain | Residue |
| A | SER22 |
| A | SER23 |
| A | ASP24 |
| A | CL101 |
| A | HOH202 |
| B | SER23 |
| C | SER22 |
| C | NA102 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide LEU B 46 and NH2 B 47 |
| Chain | Residue |
| B | ILE42 |
| B | LEU43 |
| B | ARG45 |
| B | HOH101 |
| D | ARG45 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide ACE C 21 and SER C 22 |
| Chain | Residue |
| A | CL101 |
| B | SER22 |
| B | SER23 |
| B | ASP24 |
| C | SER23 |
| C | NA102 |
| D | ACE21 |
| D | SER22 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide LEU C 46 and NH2 C 47 |
| Chain | Residue |
| A | ARG45 |
| C | ILE42 |
| C | LEU43 |
| C | ASP44 |
| C | ARG45 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide ACE D 21 and SER D 22 |
| Chain | Residue |
| A | ACE21 |
| A | SER22 |
| A | HOH202 |
| C | SER22 |
| C | SER23 |
| C | ASP24 |
| C | NA102 |
| D | SER23 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide LEU D 46 and NH2 D 47 |
| Chain | Residue |
| B | ARG45 |
| D | ILE42 |
| D | LEU43 |
| D | ASP44 |
| D | ARG45 |
| D | HOH101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Signal-anchor for type III membrane protein","evidences":[{"source":"HAMAP-Rule","id":"MF_04069","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter","evidences":[{"source":"HAMAP-Rule","id":"MF_04069","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Seems to be involved in pH gating","evidences":[{"source":"HAMAP-Rule","id":"MF_04069","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
