6BMZ
Influenza A M2 transmembrane domain bound to a spiroadamantane inhibitor
Summary for 6BMZ
| Entry DOI | 10.2210/pdb6bmz/pdb |
| Descriptor | Matrix protein 2, (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | influenza m2, proton channel, membrane protein, spiroadamantane |
| Biological source | Influenza A virus |
| Total number of polymer chains | 16 |
| Total formula weight | 45088.72 |
| Authors | Thomaston, J.L.,DeGrado, W.F. (deposition date: 2017-11-15, release date: 2018-09-19, Last modification date: 2023-10-04) |
| Primary citation | Thomaston, J.L.,Polizzi, N.F.,Konstantinidi, A.,Wang, J.,Kolocouris, A.,DeGrado, W.F. Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140:15219-15226, 2018 Cited by PubMed: 30165017DOI: 10.1021/jacs.8b06741 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.634 Å) |
Structure validation
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