6BMZ
Influenza A M2 transmembrane domain bound to a spiroadamantane inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0015078 | molecular_function | proton transmembrane transporter activity |
A | 0033644 | cellular_component | host cell membrane |
A | 0055036 | cellular_component | virion membrane |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0015078 | molecular_function | proton transmembrane transporter activity |
B | 0033644 | cellular_component | host cell membrane |
B | 0055036 | cellular_component | virion membrane |
B | 1902600 | biological_process | proton transmembrane transport |
C | 0015078 | molecular_function | proton transmembrane transporter activity |
C | 0033644 | cellular_component | host cell membrane |
C | 0055036 | cellular_component | virion membrane |
C | 1902600 | biological_process | proton transmembrane transport |
D | 0015078 | molecular_function | proton transmembrane transporter activity |
D | 0033644 | cellular_component | host cell membrane |
D | 0055036 | cellular_component | virion membrane |
D | 1902600 | biological_process | proton transmembrane transport |
E | 0015078 | molecular_function | proton transmembrane transporter activity |
E | 0033644 | cellular_component | host cell membrane |
E | 0055036 | cellular_component | virion membrane |
E | 1902600 | biological_process | proton transmembrane transport |
F | 0015078 | molecular_function | proton transmembrane transporter activity |
F | 0033644 | cellular_component | host cell membrane |
F | 0055036 | cellular_component | virion membrane |
F | 1902600 | biological_process | proton transmembrane transport |
G | 0015078 | molecular_function | proton transmembrane transporter activity |
G | 0033644 | cellular_component | host cell membrane |
G | 0055036 | cellular_component | virion membrane |
G | 1902600 | biological_process | proton transmembrane transport |
H | 0015078 | molecular_function | proton transmembrane transporter activity |
H | 0033644 | cellular_component | host cell membrane |
H | 0055036 | cellular_component | virion membrane |
H | 1902600 | biological_process | proton transmembrane transport |
I | 0015078 | molecular_function | proton transmembrane transporter activity |
I | 0033644 | cellular_component | host cell membrane |
I | 0055036 | cellular_component | virion membrane |
I | 1902600 | biological_process | proton transmembrane transport |
J | 0015078 | molecular_function | proton transmembrane transporter activity |
J | 0033644 | cellular_component | host cell membrane |
J | 0055036 | cellular_component | virion membrane |
J | 1902600 | biological_process | proton transmembrane transport |
K | 0015078 | molecular_function | proton transmembrane transporter activity |
K | 0033644 | cellular_component | host cell membrane |
K | 0055036 | cellular_component | virion membrane |
K | 1902600 | biological_process | proton transmembrane transport |
L | 0015078 | molecular_function | proton transmembrane transporter activity |
L | 0033644 | cellular_component | host cell membrane |
L | 0055036 | cellular_component | virion membrane |
L | 1902600 | biological_process | proton transmembrane transport |
M | 0015078 | molecular_function | proton transmembrane transporter activity |
M | 0033644 | cellular_component | host cell membrane |
M | 0055036 | cellular_component | virion membrane |
M | 1902600 | biological_process | proton transmembrane transport |
N | 0015078 | molecular_function | proton transmembrane transporter activity |
N | 0033644 | cellular_component | host cell membrane |
N | 0055036 | cellular_component | virion membrane |
N | 1902600 | biological_process | proton transmembrane transport |
O | 0015078 | molecular_function | proton transmembrane transporter activity |
O | 0033644 | cellular_component | host cell membrane |
O | 0055036 | cellular_component | virion membrane |
O | 1902600 | biological_process | proton transmembrane transport |
P | 0015078 | molecular_function | proton transmembrane transporter activity |
P | 0033644 | cellular_component | host cell membrane |
P | 0055036 | cellular_component | virion membrane |
P | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue E01 A 101 |
Chain | Residue |
A | ALA30 |
A | SER31 |
A | HOH201 |
B | SER31 |
C | ALA30 |
C | SER31 |
D | ALA30 |
D | SER31 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue E01 E 101 |
Chain | Residue |
E | SER31 |
F | SER31 |
G | SER31 |
G | HOH201 |
H | ALA30 |
H | SER31 |
E | ALA30 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue E01 K 101 |
Chain | Residue |
I | SER31 |
J | HOH101 |
K | ALA30 |
K | SER31 |
K | GLY34 |
L | ALA30 |
L | SER31 |
L | HOH103 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue E01 P 101 |
Chain | Residue |
M | ALA30 |
N | ALA30 |
N | SER31 |
N | GLY34 |
O | ALA30 |
P | ALA30 |
P | GLY34 |
P | HOH201 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for Di-peptide LEU B 46 and NH2 B 47 |
Chain | Residue |
B | ILE42 |
B | LEU43 |
B | ASP44 |
B | ARG45 |
F | ARG45 |
G | PRO25 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for Di-peptide LEU C 46 and NH2 C 47 |
Chain | Residue |
C | ILE42 |
C | LEU43 |
C | ASP44 |
C | ARG45 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for Di-peptide LEU D 46 and NH2 D 47 |
Chain | Residue |
A | SER23 |
D | ILE42 |
D | LEU43 |
D | ASP44 |
D | ARG45 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for Di-peptide LEU E 46 and NH2 E 47 |
Chain | Residue |
E | ILE42 |
E | LEU43 |
E | ASP44 |
E | ARG45 |
O | ARG45 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for Di-peptide LEU F 46 and NH2 F 47 |
Chain | Residue |
B | ARG45 |
C | PRO25 |
F | ILE42 |
F | LEU43 |
F | ASP44 |
F | ARG45 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for Di-peptide LEU G 46 and NH2 G 47 |
Chain | Residue |
G | ILE42 |
G | LEU43 |
G | ASP44 |
G | ARG45 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for Di-peptide LEU H 46 and NH2 H 47 |
Chain | Residue |
E | SER23 |
E | ASP24 |
H | ILE42 |
H | LEU43 |
H | ASP44 |
H | ARG45 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for Di-peptide LEU I 46 and NH2 I 47 |
Chain | Residue |
I | ILE42 |
I | LEU43 |
I | ASP44 |
I | ARG45 |
site_id | AD4 |
Number of Residues | 4 |
Details | binding site for Di-peptide LEU J 46 and NH2 J 47 |
Chain | Residue |
J | ILE42 |
J | LEU43 |
J | ASP44 |
J | ARG45 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for Di-peptide LEU K 46 and NH2 K 47 |
Chain | Residue |
K | ILE42 |
K | LEU43 |
K | ASP44 |
K | ARG45 |
L | PRO25 |
P | SER23 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for Di-peptide LEU L 46 and NH2 L 47 |
Chain | Residue |
H | PRO25 |
L | ILE42 |
L | LEU43 |
L | ASP44 |
L | ARG45 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for Di-peptide LEU M 46 and NH2 M 47 |
Chain | Residue |
I | ASP44 |
M | ILE42 |
M | LEU43 |
M | ASP44 |
M | ARG45 |
site_id | AD8 |
Number of Residues | 5 |
Details | binding site for Di-peptide LEU N 46 and NH2 N 47 |
Chain | Residue |
F | PRO25 |
N | ILE42 |
N | LEU43 |
N | ASP44 |
N | ARG45 |
site_id | AD9 |
Number of Residues | 5 |
Details | binding site for Di-peptide LEU O 46 and NH2 O 47 |
Chain | Residue |
O | ARG45 |
P | PRO25 |
O | ILE42 |
O | LEU43 |
O | ASP44 |
site_id | AE1 |
Number of Residues | 3 |
Details | binding site for Di-peptide LEU P 46 and NH2 P 47 |
Chain | Residue |
P | ILE42 |
P | ASP44 |
P | ARG45 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 320 |
Details | TRANSMEM: Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069 |
Chain | Residue | Details |
A | SER23-LEU43 | |
J | SER23-LEU43 | |
K | SER23-LEU43 | |
L | SER23-LEU43 | |
M | SER23-LEU43 | |
N | SER23-LEU43 | |
O | SER23-LEU43 | |
P | SER23-LEU43 | |
B | SER23-LEU43 | |
C | SER23-LEU43 | |
D | SER23-LEU43 | |
E | SER23-LEU43 | |
F | SER23-LEU43 | |
G | SER23-LEU43 | |
H | SER23-LEU43 | |
I | SER23-LEU43 |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | SITE: Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069 |
Chain | Residue | Details |
A | HIS37 | |
J | HIS37 | |
K | HIS37 | |
L | HIS37 | |
M | HIS37 | |
N | HIS37 | |
O | HIS37 | |
P | HIS37 | |
B | HIS37 | |
C | HIS37 | |
D | HIS37 | |
E | HIS37 | |
F | HIS37 | |
G | HIS37 | |
H | HIS37 | |
I | HIS37 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | SITE: Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069 |
Chain | Residue | Details |
A | TRP41 | |
J | TRP41 | |
K | TRP41 | |
L | TRP41 | |
M | TRP41 | |
N | TRP41 | |
O | TRP41 | |
P | TRP41 | |
B | TRP41 | |
C | TRP41 | |
D | TRP41 | |
E | TRP41 | |
F | TRP41 | |
G | TRP41 | |
H | TRP41 | |
I | TRP41 |