Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6BMZ

Influenza A M2 transmembrane domain bound to a spiroadamantane inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015078	molecular_function	proton transmembrane transporter activity
A	0033644	cellular_component	host cell membrane
A	0055036	cellular_component	virion membrane
A	1902600	biological_process	proton transmembrane transport
B	0015078	molecular_function	proton transmembrane transporter activity
B	0033644	cellular_component	host cell membrane
B	0055036	cellular_component	virion membrane
B	1902600	biological_process	proton transmembrane transport
C	0015078	molecular_function	proton transmembrane transporter activity
C	0033644	cellular_component	host cell membrane
C	0055036	cellular_component	virion membrane
C	1902600	biological_process	proton transmembrane transport
D	0015078	molecular_function	proton transmembrane transporter activity
D	0033644	cellular_component	host cell membrane
D	0055036	cellular_component	virion membrane
D	1902600	biological_process	proton transmembrane transport
E	0015078	molecular_function	proton transmembrane transporter activity
E	0033644	cellular_component	host cell membrane
E	0055036	cellular_component	virion membrane
E	1902600	biological_process	proton transmembrane transport
F	0015078	molecular_function	proton transmembrane transporter activity
F	0033644	cellular_component	host cell membrane
F	0055036	cellular_component	virion membrane
F	1902600	biological_process	proton transmembrane transport
G	0015078	molecular_function	proton transmembrane transporter activity
G	0033644	cellular_component	host cell membrane
G	0055036	cellular_component	virion membrane
G	1902600	biological_process	proton transmembrane transport
H	0015078	molecular_function	proton transmembrane transporter activity
H	0033644	cellular_component	host cell membrane
H	0055036	cellular_component	virion membrane
H	1902600	biological_process	proton transmembrane transport
I	0015078	molecular_function	proton transmembrane transporter activity
I	0033644	cellular_component	host cell membrane
I	0055036	cellular_component	virion membrane
I	1902600	biological_process	proton transmembrane transport
J	0015078	molecular_function	proton transmembrane transporter activity
J	0033644	cellular_component	host cell membrane
J	0055036	cellular_component	virion membrane
J	1902600	biological_process	proton transmembrane transport
K	0015078	molecular_function	proton transmembrane transporter activity
K	0033644	cellular_component	host cell membrane
K	0055036	cellular_component	virion membrane
K	1902600	biological_process	proton transmembrane transport
L	0015078	molecular_function	proton transmembrane transporter activity
L	0033644	cellular_component	host cell membrane
L	0055036	cellular_component	virion membrane
L	1902600	biological_process	proton transmembrane transport
M	0015078	molecular_function	proton transmembrane transporter activity
M	0033644	cellular_component	host cell membrane
M	0055036	cellular_component	virion membrane
M	1902600	biological_process	proton transmembrane transport
N	0015078	molecular_function	proton transmembrane transporter activity
N	0033644	cellular_component	host cell membrane
N	0055036	cellular_component	virion membrane
N	1902600	biological_process	proton transmembrane transport
O	0015078	molecular_function	proton transmembrane transporter activity
O	0033644	cellular_component	host cell membrane
O	0055036	cellular_component	virion membrane
O	1902600	biological_process	proton transmembrane transport
P	0015078	molecular_function	proton transmembrane transporter activity
P	0033644	cellular_component	host cell membrane
P	0055036	cellular_component	virion membrane
P	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue E01 A 101

Chain	Residue
A	ALA30
A	SER31
A	HOH201
B	SER31
C	ALA30
C	SER31
D	ALA30
D	SER31

site_id	AC2
Number of Residues	7
Details	binding site for residue E01 E 101

Chain	Residue
E	SER31
F	SER31
G	SER31
G	HOH201
H	ALA30
H	SER31
E	ALA30

site_id	AC3
Number of Residues	8
Details	binding site for residue E01 K 101

Chain	Residue
I	SER31
J	HOH101
K	ALA30
K	SER31
K	GLY34
L	ALA30
L	SER31
L	HOH103

site_id	AC4
Number of Residues	8
Details	binding site for residue E01 P 101

Chain	Residue
M	ALA30
N	ALA30
N	SER31
N	GLY34
O	ALA30
P	ALA30
P	GLY34
P	HOH201

site_id	AC5
Number of Residues	6
Details	binding site for Di-peptide LEU B 46 and NH2 B 47

Chain	Residue
B	ILE42
B	LEU43
B	ASP44
B	ARG45
F	ARG45
G	PRO25

site_id	AC6
Number of Residues	4
Details	binding site for Di-peptide LEU C 46 and NH2 C 47

Chain	Residue
C	ILE42
C	LEU43
C	ASP44
C	ARG45

site_id	AC7
Number of Residues	5
Details	binding site for Di-peptide LEU D 46 and NH2 D 47

Chain	Residue
A	SER23
D	ILE42
D	LEU43
D	ASP44
D	ARG45

site_id	AC8
Number of Residues	5
Details	binding site for Di-peptide LEU E 46 and NH2 E 47

Chain	Residue
E	ILE42
E	LEU43
E	ASP44
E	ARG45
O	ARG45

site_id	AC9
Number of Residues	6
Details	binding site for Di-peptide LEU F 46 and NH2 F 47

Chain	Residue
B	ARG45
C	PRO25
F	ILE42
F	LEU43
F	ASP44
F	ARG45

site_id	AD1
Number of Residues	4
Details	binding site for Di-peptide LEU G 46 and NH2 G 47

Chain	Residue
G	ILE42
G	LEU43
G	ASP44
G	ARG45

site_id	AD2
Number of Residues	6
Details	binding site for Di-peptide LEU H 46 and NH2 H 47

Chain	Residue
E	SER23
E	ASP24
H	ILE42
H	LEU43
H	ASP44
H	ARG45

site_id	AD3
Number of Residues	4
Details	binding site for Di-peptide LEU I 46 and NH2 I 47

Chain	Residue
I	ILE42
I	LEU43
I	ASP44
I	ARG45

site_id	AD4
Number of Residues	4
Details	binding site for Di-peptide LEU J 46 and NH2 J 47

Chain	Residue
J	ILE42
J	LEU43
J	ASP44
J	ARG45

site_id	AD5
Number of Residues	6
Details	binding site for Di-peptide LEU K 46 and NH2 K 47

Chain	Residue
K	ILE42
K	LEU43
K	ASP44
K	ARG45
L	PRO25
P	SER23

site_id	AD6
Number of Residues	5
Details	binding site for Di-peptide LEU L 46 and NH2 L 47

Chain	Residue
H	PRO25
L	ILE42
L	LEU43
L	ASP44
L	ARG45

site_id	AD7
Number of Residues	5
Details	binding site for Di-peptide LEU M 46 and NH2 M 47

Chain	Residue
I	ASP44
M	ILE42
M	LEU43
M	ASP44
M	ARG45

site_id	AD8
Number of Residues	5
Details	binding site for Di-peptide LEU N 46 and NH2 N 47

Chain	Residue
F	PRO25
N	ILE42
N	LEU43
N	ASP44
N	ARG45

site_id	AD9
Number of Residues	5
Details	binding site for Di-peptide LEU O 46 and NH2 O 47

Chain	Residue
O	ARG45
P	PRO25
O	ILE42
O	LEU43
O	ASP44

site_id	AE1
Number of Residues	3
Details	binding site for Di-peptide LEU P 46 and NH2 P 47

Chain	Residue
P	ILE42
P	ASP44
P	ARG45

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	TRANSMEM: Helical; Signal-anchor for type III membrane protein => ECO:0000255\|HAMAP-Rule:MF_04069

Chain	Residue	Details
A	SER23-LEU43
B	SER23-LEU43
C	SER23-LEU43
D	SER23-LEU43
E	SER23-LEU43
F	SER23-LEU43
G	SER23-LEU43
H	SER23-LEU43
I	SER23-LEU43
J	SER23-LEU43
K	SER23-LEU43
L	SER23-LEU43
M	SER23-LEU43
N	SER23-LEU43
O	SER23-LEU43
P	SER23-LEU43

site_id	SWS_FT_FI2
Number of Residues	16
Details	SITE: Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255\|HAMAP-Rule:MF_04069

Chain	Residue	Details
A	HIS37
B	HIS37
C	HIS37
D	HIS37
E	HIS37
F	HIS37
G	HIS37
H	HIS37
I	HIS37
J	HIS37
K	HIS37
L	HIS37
M	HIS37
N	HIS37
O	HIS37
P	HIS37

site_id	SWS_FT_FI3
Number of Residues	16
Details	SITE: Seems to be involved in pH gating => ECO:0000255\|HAMAP-Rule:MF_04069

Chain	Residue	Details
A	TRP41
B	TRP41
C	TRP41
D	TRP41
E	TRP41
F	TRP41
G	TRP41
H	TRP41
I	TRP41
J	TRP41
K	TRP41
L	TRP41
M	TRP41
N	TRP41
O	TRP41
P	TRP41

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)