6US8

Influenza A M2 proton channel wild type TM domain bound to S-rimantadine

Summary for 6US8

• Entry DOI: 10.2210/pdb6us8/pdb
• Descriptor: Matrix protein 2, CHLORIDE ION, (1S)-1-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-amine, ... (4 entities in total)
• Functional Keywords: proton channel, rimantadine, membrane protein
• Biological source: Influenza A virus (A/Jinfang/132/2002(H3N2))
• Total number of polymer chains: 16
• Total formula weight: 46362.88

Authors

Thomaston, J.L.,DeGrado, W.F. (deposition date: 2019-10-25, release date: 2020-10-28, Last modification date: 2023-10-11)

• Primary citation: Thomaston, J.L.,Samways, M.L.,Konstantinidi, A.,Ma, C.,Hu, Y.,Bruce Macdonald, H.E.,Wang, J.,Essex, J.W.,DeGrado, W.F.,Kolocouris, A.; Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity.; Biochemistry, 2021; PubMed: 34342217; DOI: 10.1021/acs.biochem.1c00437

Experimental method

X-RAY DIFFRACTION (1.7 Å)