6HYU

Crystal structure of DHX8 helicase bound to single stranded poly-adenine RNA

Summary for 6HYU

• Entry DOI: 10.2210/pdb6hyu/pdb
• Descriptor: ATP-dependent RNA helicase DHX8, RNA (5'-R(*AP*AP*AP*AP*AP*A)-3'), RNA (5'-R(*A*AP*A)-3'), ... (5 entities in total)
• Functional Keywords: helicase, splicing, rna, rna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 156580.13

Authors

Felisberto-Rodrigues, C.,Thomas, J.C.,McAndrew, P.C.,Le Bihan, Y.V.,Burke, R.,Workman, P.,van Montfort, R.L.M. (deposition date: 2018-10-22, release date: 2019-08-28, Last modification date: 2019-09-25)

• Primary citation: Felisberto-Rodrigues, C.,Thomas, J.C.,McAndrew, C.,Le Bihan, Y.V.,Burke, R.,Workman, P.,van Montfort, R.L.M.; Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.; Biochem.J., 476:2521-2543, 2019; PubMed: 31409651; DOI: 10.1042/BCJ20190383

Experimental method

X-RAY DIFFRACTION (3.22 Å)