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PDB: 42 results
6D04
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BU of 6d04 by Molmil
Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; two molecules of parasite ligand, subclass 1.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Gruszczyk, J, Huang, R.K, Hong, C, Yu, Z, Tham, W.H.
Deposit date:2018-04-10
Release date:2018-06-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Nature, 559, 2018
4Z8N
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BU of 4z8n by Molmil
Crystal structure of the erythrocyte-binding domain from Plasmodium vivax reticulocyte-binding protein 2a (PvRBP2a)
Descriptor: CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Gruszczyk, J, Tham, W.H.
Deposit date:2015-04-09
Release date:2015-12-16
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.124 Å)
Cite:Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement.
Proc.Natl.Acad.Sci.USA, 113, 2016
6WOZ
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BU of 6woz by Molmil
Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 251249
Descriptor: 251249 Fab heavy chain, 251249 Fab light chain, reticulocyte binding protein 2b
Authors:Chan, L.J, Dietrich, M.H, Tham, W.H.
Deposit date:2020-04-26
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b.
Nat Commun, 12, 2021
6WNO
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BU of 6wno by Molmil
Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 243244
Descriptor: 243244 Fab heavy chain, 243244 Fab light chain, Plasmodium vivax reticulocyte binding protein 2b
Authors:Chan, L.J, Dietrich, M.H, Tham, W.H.
Deposit date:2020-04-23
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b.
Nat Commun, 12, 2021
6WTY
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BU of 6wty by Molmil
Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 253245
Descriptor: 253245 Fab heavy chain, 253245 Fab light chain, reticulocyte binding protein 2b
Authors:Chan, L.J, Dietrich, M.H, Tham, W.H.
Deposit date:2020-05-04
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.481 Å)
Cite:Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b.
Nat Commun, 12, 2021
6WTV
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BU of 6wtv by Molmil
Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 258259
Descriptor: 258259 Fab heavy chain, 258259 Fab light chain, reticulocyte binding protein 2b
Authors:Chan, L.J, Dietrich, M.H, Tham, W.H.
Deposit date:2020-05-04
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b.
Nat Commun, 12, 2021
5W53
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BU of 5w53 by Molmil
Crystal structure of the erythrocyte-binding domain from Plasmodium vivax reticulocyte-binding protein 2b (PvRBP2b)
Descriptor: POTASSIUM ION, Reticulocyte binding protein 2, putative, ...
Authors:Gruszczyk, J, Tham, W.H.
Deposit date:2017-06-13
Release date:2017-11-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.
Science, 359, 2018
7RR0
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BU of 7rr0 by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 222
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PDI 222 Fab Heavy Chain, PDI 222 Fab Light Chain, ...
Authors:Pymm, P, Glukhova, A, Black, K.A, Tham, W.H.
Deposit date:2021-08-08
Release date:2021-10-06
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
2MCY
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BU of 2mcy by Molmil
CR1 Sushi domains 2 and 3
Descriptor: Complement receptor type 1
Authors:Park, H.J, Guariento, M.J, Maciejewski, M, Hauart, R, Tham, W, Cowman, A.F, Schmidt, C.Q, Martens, H, Liszewski, K.M, Hourcade, D, Barlow, P.N, Atkinson, J.P.
Deposit date:2013-08-27
Release date:2013-11-13
Last modified:2014-01-22
Method:SOLUTION NMR
Cite:Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor.
J.Biol.Chem., 289, 2014
2MCZ
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BU of 2mcz by Molmil
CR1 Sushi domains 1 and 2
Descriptor: Complement receptor type 1
Authors:Park, H.J, Guariento, M.J, Maciejewski, M, Hauart, R, Tham, W, Cowman, A.F, Schmidt, C.Q, Martens, H, Liszewski, K.M, Hourcade, D, Barlow, P.N, Atkinson, J.P.
Deposit date:2013-08-27
Release date:2013-11-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Using Mutagenesis and Structural Biology to Map the Binding Site for the Plasmodium falciparum Merozoite Protein PfRh4 on the Human Immune Adherence Receptor.
J.Biol.Chem., 289, 2014
7S7R
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BU of 7s7r by Molmil
Plasmodium falciparum protein Pf12 bound to nanobody G7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Merozoite surface protein P12, Nanobody G7, ...
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2021-09-17
Release date:2022-03-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure of the Pf12 and Pf41 heterodimeric complex of Plasmodium falciparum 6-cysteine proteins.
FEMS Microbes, 3, 2022
7USS
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BU of 7uss by Molmil
Plasmodium falciparum protein Pfs230 Pro-D1D2 - Structure of the first two 6-cysteine domains with N-terminal extension
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Gametocyte surface protein P230, ...
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2022-04-25
Release date:2022-12-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nanobodies against Pfs230 block Plasmodium falciparum transmission.
Biochem.J., 479, 2022
7UST
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BU of 7ust by Molmil
Plasmodium falciparum protein Pfs230 D1 in complex with nanobody F5
Descriptor: Gametocyte surface protein P230, Nanobody F5, SULFATE ION
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2022-04-25
Release date:2022-12-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nanobodies against Pfs230 block Plasmodium falciparum transmission.
Biochem.J., 479, 2022
7USR
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BU of 7usr by Molmil
Plasmodium falciparum protein Pfs230 D1D2 - Structure of the first two 6-cysteine domains
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Gametocyte surface protein P230
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2022-04-25
Release date:2022-12-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Nanobodies against Pfs230 block Plasmodium falciparum transmission.
Biochem.J., 479, 2022
7USV
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BU of 7usv by Molmil
Plasmodium falciparum protein Pfs230 D1 in complex with nanobody F10
Descriptor: Gametocyte surface protein P230, Nanobody F10, SULFATE ION
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2022-04-25
Release date:2022-12-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Nanobodies against Pfs230 block Plasmodium falciparum transmission.
Biochem.J., 479, 2022
7LX5
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BU of 7lx5 by Molmil
The SARS-CoV-2 spike protein receptor binding domain bound to neutralizing nanobodies WNb 2 and WNb 10
Descriptor: Spike glycoprotein, WNb 10, WNb 2
Authors:Pymm, P, Glukhova, A, Tham, W.-H.
Deposit date:2021-03-03
Release date:2021-05-05
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice.
Proc.Natl.Acad.Sci.USA, 118, 2021
8TZU
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BU of 8tzu by Molmil
OC43 S1b domain in complex with WNb 293 and WNb 317
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Pymm, P, Feng, J, Tham, W.H.
Deposit date:2023-08-27
Release date:2024-05-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:OC43 S1b domain in complex with WNb 293 and WNb 317
To Be Published
7S7Q
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BU of 7s7q by Molmil
Heterodimeric complex of Pf12 and Pf41 of Plasmodium falciparum
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Merozoite surface protein P12, ...
Authors:Dietrich, M.H, Tham, W.H.
Deposit date:2021-09-17
Release date:2022-03-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of the Pf12 and Pf41 heterodimeric complex of Plasmodium falciparum 6-cysteine proteins.
FEMS Microbes, 3, 2022
7MZK
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BU of 7mzk by Molmil
SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 96
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, ...
Authors:Pymm, P, Dietrich, M.H, Tan, L.L, Chan, L.J, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZJ
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BU of 7mzj by Molmil
SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 93
Descriptor: GLYCEROL, PDI 93 heavy chain, PDI 93 light chain, ...
Authors:Pymm, P, Dietrich, M.H, Tan, L.L, Chan, L.J, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZL
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BU of 7mzl by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 210
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PDI 210 heavy chain, PDI 210 light chain, ...
Authors:Pymm, P, Chan, L.J, Dietrich, M.H, Tan, L.L, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
6WTU
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BU of 6wtu by Molmil
Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) bound to human monoclonal antibody 273264
Descriptor: 273264 Fab heavy chain, 273264 Fab light chain, reticulocyte binding protein 2b
Authors:Chan, L.J, Dietrich, M.H, Tham, W.H.
Deposit date:2020-05-04
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b.
Nat Commun, 12, 2021
7MZG
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BU of 7mzg by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 42
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, PDI 42 heavy chain, ...
Authors:Pymm, P, Chan, L.J, Dietrich, M.H, Tan, L.L, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZH
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BU of 7mzh by Molmil
SARS-CoV-2 receptor binding domain bound to Fab WCSL 119
Descriptor: Spike protein S1, WCSL 119 heavy chain, WCSL 119 light chain, ...
Authors:Pymm, P, Tan, L.L, Dietrich, M.H, Chan, L.J, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZF
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BU of 7mzf by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 37
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ...
Authors:Pymm, P, Chan, L.J, Dietrich, M.H, Tan, L.L, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021

 

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