5I3L
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![BU of 5i3l by Molmil](/molmil-images/mine/5i3l) | DPF3b in complex with H3K14ac peptide | Descriptor: | 1,2-ETHANEDIOL, H3K14ac peptide, SODIUM ION, ... | Authors: | Tempel, W, Liu, Y, Walker, J.R, Zhao, A, Qin, S, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2016-02-10 | Release date: | 2016-02-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of DPF3b in complex with an acetylated histone peptide. J.Struct.Biol., 195, 2016
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4PWY
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![BU of 4pwy by Molmil](/molmil-images/mine/4pwy) | Crystal structure of a Calmodulin-lysine N-methyltransferase fragment | Descriptor: | Calmodulin-lysine N-methyltransferase, GLYCEROL, MALONATE ION, ... | Authors: | Tempel, W, Hong, B.S, Walker, J.R, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-03-21 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a Calmodulin-lysine N-methyltransferase fragment TO BE PUBLISHED
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1HQL
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![BU of 1hql by Molmil](/molmil-images/mine/1hql) | The xenograft antigen in complex with the B4 isolectin of Griffonia simplicifolia lectin-1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, LECTIN, ... | Authors: | Tempel, W, Lipscomb, L.A, Rose, J.P, Woods, R.J. | Deposit date: | 2000-12-18 | Release date: | 2002-01-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The xenograft antigen bound to Griffonia simplicifolia lectin 1-B(4). X-ray crystal structure of the complex and molecular dynamics characterization of the binding site. J.Biol.Chem., 277, 2002
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4P7A
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![BU of 4p7a by Molmil](/molmil-images/mine/4p7a) | Crystal Structure of human MLH1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Mlh1, MAGNESIUM ION, ... | Authors: | Tempel, W, Lam, R, Zeng, H, Walker, J.R, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2014-03-26 | Release date: | 2014-04-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome. Acta Crystallogr.,Sect.F, 71, 2015
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2REO
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![BU of 2reo by Molmil](/molmil-images/mine/2reo) | Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Putative sulfotransferase 1C3 | Authors: | Tempel, W, Pan, P, Dong, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-09-26 | Release date: | 2007-10-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.651 Å) | Cite: | Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP. To be Published
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6EDF
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![BU of 6edf by Molmil](/molmil-images/mine/6edf) | Fragment of a tyrosine-protein kinase | Descriptor: | FYN, GLYCEROL, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Huang, H, Sochirca, I, Liu, K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Sidhu, S.S, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2018-08-09 | Release date: | 2018-08-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Fragment of a tyrosine-protein kinase To be Published
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1NXC
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![BU of 1nxc by Molmil](/molmil-images/mine/1nxc) | Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases) | Descriptor: | CALCIUM ION, Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Tempel, W, Liu, Z.-J, Karaveg, K, Rose, J, Moremen, K.W, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2003-02-10 | Release date: | 2004-05-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases J.Biol.Chem., 279, 2004
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6P9G
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![BU of 6p9g by Molmil](/molmil-images/mine/6p9g) | Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid | Descriptor: | (2R)-2-(4-oxoquinazolin-3(4H)-yl)propanoic acid, UNKNOWN ATOM OR ION, Ubiquitin carboxyl-terminal hydrolase 5, ... | Authors: | Tempel, W, Mann, M.K, Harding, R.J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Schapira, M, Structural Genomics Consortium (SGC) | Deposit date: | 2019-06-10 | Release date: | 2019-09-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. J.Med.Chem., 62, 2019
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5KCH
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![BU of 5kch by Molmil](/molmil-images/mine/5kch) | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy into weak electron density | Descriptor: | 4-methoxy-N-[(pyridin-2-yl)methyl]aniline, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase SETDB1, ... | Authors: | Tempel, W, Harding, R.J, Mader, P, Dobrovetsky, E, Walker, J.R, Brown, P.J, Schapira, M, Collins, P, Pearce, N, Brandao-Neto, J, Douangamath, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Santhakumar, V, Structural Genomics Consortium (SGC) | Deposit date: | 2016-06-06 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy To Be Published
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5KCO
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![BU of 5kco by Molmil](/molmil-images/mine/5kco) | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy | Descriptor: | DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase SETDB1, SULFATE ION, ... | Authors: | Tempel, W, Harding, R.J, Mader, P, Dobrovetsky, E, Walker, J.R, Brown, P.J, Schapira, M, Collins, P, Pearce, N, Brandao-Neto, J, Douangamath, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Santhakumar, V, Structural Genomics Consortium (SGC) | Deposit date: | 2016-06-06 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy To Be Published
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6MEW
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![BU of 6mew by Molmil](/molmil-images/mine/6mew) | RFXANK ankyrin repeats in complex with a RFX7 peptide | Descriptor: | DNA-binding protein RFXANK, RFX7 peptide, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Xu, C, Dong, A, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2018-09-07 | Release date: | 2018-10-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | RFXANK ankyrin repeats in complex with a RFX7 peptide to be published
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2AYV
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![BU of 2ayv by Molmil](/molmil-images/mine/2ayv) | Crystal structure of a putative ubiquitin-conjugating enzyme E2 from Toxoplasma gondii | Descriptor: | UNKNOWN ATOM OR ION, ubiquitin-conjugating enzyme E2 | Authors: | Tempel, W, Dong, A, Zhao, Y, Lew, J, Alam, Z, Melone, M, Wasney, G, Kozieradzki, I, Vedadi, M, Arrowsmith, C, Sundstrom, M, Weigelt, J, Edwards, A, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | Deposit date: | 2005-09-08 | Release date: | 2005-09-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol.Biochem.Parasitol., 151, 2007
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6N8U
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![BU of 6n8u by Molmil](/molmil-images/mine/6n8u) | |
1NNH
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![BU of 1nnh by Molmil](/molmil-images/mine/1nnh) | Hypothetical protein from Pyrococcus furiosus Pfu-1801964 | Descriptor: | SODIUM ION, asparaginyl-tRNA synthetase-related peptide | Authors: | Tempel, W, Liu, Z.-J, Schubot, F.D, Shah, A, Arendall III, W.B, Rose, J.P, Richardson, D.C, Richardson, J.S, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2003-01-13 | Release date: | 2004-02-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Hypothetical protein from Pyrococcus furiosus Pfu-1801964 To be published
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1UPS
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![BU of 1ups by Molmil](/molmil-images/mine/1ups) | GlcNAc[alpha]1-4Gal releasing endo-[beta]-galactosidase from Clostridium perfringens | Descriptor: | CALCIUM ION, GLCNAC-ALPHA-1,4-GAL-RELEASING ENDO-BETA-GALACTOSIDASE | Authors: | Tempel, W, Liu, Z.-J, Horanyi, P.S, Deng, L, Lee, D, Newton, M.G, Rose, J.P, Ashida, H, Li, S.-C, Li, Y.-T, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2003-10-10 | Release date: | 2004-11-25 | Last modified: | 2019-08-21 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Three-dimensional structure of GlcNAcalpha1-4Gal releasing endo-beta-galactosidase from Clostridium perfringens. Proteins, 59, 2005
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3BPJ
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![BU of 3bpj by Molmil](/molmil-images/mine/3bpj) | Crystal structure of human translation initiation factor 3, subunit 1 alpha | Descriptor: | Eukaryotic translation initiation factor 3 subunit J, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Nedyalkova, L, Hong, B, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-12-18 | Release date: | 2008-01-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of human translation initiation factor 3, subunit 1 alpha. To be Published
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2B25
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![BU of 2b25 by Molmil](/molmil-images/mine/2b25) | Human putative tRNA(1-methyladenosine)methyltransferase | Descriptor: | S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, hypothetical protein | Authors: | Tempel, W, Wu, H, Dong, A, Zeng, H, Loppnau, P, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2005-09-16 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Human putative tRNA(1-methyladenosine)methyltransferase To be Published
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2B6H
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![BU of 2b6h by Molmil](/molmil-images/mine/2b6h) | Structure of human ADP-ribosylation factor 5 | Descriptor: | ADP-ribosylation factor 5, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Tempel, W, Atanassova, A, Sundarajan, E, Dimov, S, Shehab, I, Lew, J, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2005-10-01 | Release date: | 2005-10-11 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.764 Å) | Cite: | Structure of human ADP-ribosylation factor 5 To be Published
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2FG5
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![BU of 2fg5 by Molmil](/molmil-images/mine/2fg5) | Crystal structure of human RAB31 in complex with a GTP analogue | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-31 | Authors: | Tempel, W, Wang, J, Ismail, S, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2005-12-21 | Release date: | 2006-01-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Crystal structure of human RAB31 in complex with a GTP analogue To be Published
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5UPD
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![BU of 5upd by Molmil](/molmil-images/mine/5upd) | Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1) | Descriptor: | Histone-lysine N-methyltransferase NSD3, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ... | Authors: | Tempel, W, Yu, W, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2017-02-02 | Release date: | 2017-02-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1) To Be Published
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4O61
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![BU of 4o61 by Molmil](/molmil-images/mine/4o61) | Structure of human ALKBH5 crystallized in the presence of citrate | Descriptor: | CITRIC ACID, GLYCEROL, RNA demethylase ALKBH5, ... | Authors: | Tempel, W, Chao, X, Liu, K, Dong, A, Cerovina, T, He, H, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2013-12-20 | Release date: | 2014-02-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J.Biol.Chem., 289, 2014
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4OCT
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![BU of 4oct by Molmil](/molmil-images/mine/4oct) | Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, MANGANESE (II) ION, RNA demethylase ALKBH5, ... | Authors: | Tempel, W, Chao, X, Liu, K, Dong, A, Cerovina, T, He, H, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-01-09 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J.Biol.Chem., 289, 2014
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5W1Y
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![BU of 5w1y by Molmil](/molmil-images/mine/5w1y) | SETD8 in complex with a covalent inhibitor | Descriptor: | 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione, N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Yu, W, Li, Y, Blum, G, Luo, M, Pittella-Silva, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2017-06-05 | Release date: | 2017-06-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | SETD8 in complex with a covalent inhibitor to be published
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2GWH
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![BU of 2gwh by Molmil](/molmil-images/mine/2gwh) | Human Sulfotranferase SULT1C2 in complex with PAP and pentachlorophenol | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, PENTACHLOROPHENOL, Sulfotransferase 1C2, ... | Authors: | Tempel, W, Pan, P.W, Dombrovski, L, Allali-Hassani, A, Vedadi, M, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2006-05-04 | Release date: | 2006-05-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and chemical profiling of the human cytosolic sulfotransferases. Plos Biol., 5, 2007
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5C8H
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![BU of 5c8h by Molmil](/molmil-images/mine/5c8h) | Crystal structure of ORC2 C-terminal domain | Descriptor: | Origin recognition complex subunit 2, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Xu, C, Dong, A, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2015-06-25 | Release date: | 2015-07-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Crystal structure of ORC2 C-terminal domain To Be Published
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