6P9G

Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid

Summary for 6P9G

Entry DOI	10.2210/pdb6p9g/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase 5, ZINC ION, (2R)-2-(4-oxoquinazolin-3(4H)-yl)propanoic acid, ... (5 entities in total)
Functional Keywords	ubiquitin binding domain, structural genomics, structural genomics consortium, sgc, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13818.82
Authors	Tempel, W.,Mann, M.K.,Harding, R.J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Schapira, M.,Structural Genomics Consortium (SGC) (deposition date: 2019-06-10, release date: 2019-09-18, Last modification date: 2023-10-11)
Primary citation	Mann, M.K.,Franzoni, I.,de Freitas, R.F.,Tempel, W.,Houliston, S.,Smith, L.,Vedadi, M.,Arrowsmith, C.H.,Harding, R.J.,Schapira, M. Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. J.Med.Chem., 62:10144-10155, 2019 Cited by PubMed: 31663737 DOI: 10.1021/acs.jmedchem.9b00988 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation