4OCT

Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate

Summary for 4OCT

Entry DOI	10.2210/pdb4oct/pdb
Descriptor	RNA demethylase ALKBH5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ... (5 entities in total)
Functional Keywords	structural genomics, structural genomics consortium, sgc, rna demethylase, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Nucleus speckle : Q6P6C2
Total number of polymer chains	2
Total formula weight	51080.09
Authors	Tempel, W.,Chao, X.,Liu, K.,Dong, A.,Cerovina, T.,He, H.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2014-01-09, release date: 2014-04-16, Last modification date: 2023-09-20)
Primary citation	Xu, C.,Liu, K.,Tempel, W.,Demetriades, M.,Aik, W.,Schofield, C.J.,Min, J. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J.Biol.Chem., 289:17299-17311, 2014 Cited by PubMed: 24778178 DOI: 10.1074/jbc.M114.550350 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation