4OCT

Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006397	biological_process	mRNA processing
A	0035515	molecular_function	oxidative RNA demethylase activity
B	0006397	biological_process	mRNA processing
B	0035515	molecular_function	oxidative RNA demethylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 501

Chain	Residue
A	HIS204
A	ASP206
A	HIS266
A	AKG502

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AKG A 502

Chain	Residue
A	ILE268
A	ARG277
A	VAL279
A	ILE281
A	MN501
A	ASN193
A	TYR195
A	HIS204
A	ASP206
A	HIS266

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN B 501

Chain	Residue
B	HIS204
B	ASP206
B	HIS266
B	AKG502

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AKG B 502

Chain	Residue
B	ASN193
B	TYR195
B	HIS204
B	ASP206
B	HIS266
B	ILE268
B	ARG277
B	VAL279
B	ILE281
B	ARG283
B	MN501

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"35333330","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24778178","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35333330","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OCT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WKV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24616105","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24778178","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35333330","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7V4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WL0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by MAPK8 and MAPK9","evidences":[{"source":"PubMed","id":"34048572","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"37369679","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"34048572","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---