1LCD
| STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS | Descriptor: | DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), Lac Repressor, ... | Authors: | Chuprina, V.P, Rullmann, J.A.C, Lamerichs, R.M.J.N, Van Boom, J.H, Boelens, R, Kaptein, R. | Deposit date: | 1993-03-25 | Release date: | 1994-01-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. J.Mol.Biol., 234, 1993
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4E26
| BRAF in complex with an organic inhibitor 7898734 | Descriptor: | 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol, Serine/threonine-protein kinase B-raf | Authors: | Qin, J, Xie, P, Ventocilla, C, Zhou, G, Vultur, A, Chen, Q, Herlyn, M, Winkler, J, Marmorstein, R. | Deposit date: | 2012-03-07 | Release date: | 2012-05-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Identification of a Novel Family of BRAF(V600E) Inhibitors. J.Med.Chem., 55, 2012
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2LYH
| Structure of Faap24 residues 141-215 | Descriptor: | Fanconi anemia-associated protein of 24 kDa | Authors: | Wienk, H, Slootweg, J, Kaptein, R, Boelens, R, Folkers, G.E. | Deposit date: | 2012-09-18 | Release date: | 2013-05-01 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition. Nucleic Acids Res., 41, 2013
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3T0O
| Crystal Structure Analysis of Human RNase T2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Ribonuclease T2 | Authors: | Thorn, A, Kraetzner, R, Steinfeld, R, Sheldrick, G. | Deposit date: | 2011-07-20 | Release date: | 2012-07-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structure and activity of the only human RNase T2. Nucleic Acids Res., 40, 2012
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1TYO
| Isocitrate Dehydrogenase from the hyperthermophile Aeropyrum pernix in complex with etheno-NADP | Descriptor: | ETHENO-NADP, isocitrate dehydrogenase | Authors: | Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N, Ladenstein, R. | Deposit date: | 2004-07-08 | Release date: | 2005-07-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability J.Mol.Biol., 345, 2005
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2VKC
| Solution structure of the B3BP Smr domain | Descriptor: | NEDD4-BINDING PROTEIN 2 | Authors: | Diercks, T, Ab, E, Daniels, M.A, deJong, R.N, Besseling, R, Kaptein, R, Folkers, G.E. | Deposit date: | 2007-12-18 | Release date: | 2008-10-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure and Characterization of the DNA- Binding Activity of the B3BP-Smr Domain. J.Mol.Biol., 383, 2008
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7SNI
| Structure of G6PD-D200N tetramer bound to NADP+ and G6P | Descriptor: | 6-O-phosphono-beta-D-glucopyranose, Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-10-28 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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3IR8
| Red fluorescent protein mKeima at pH 7.0 | Descriptor: | Large stokes shift fluorescent protein | Authors: | Henderson, J.N, Osborn, M.F, Koon, N, Gepshtein, R, Huppert, D, Remington, S.J. | Deposit date: | 2009-08-21 | Release date: | 2009-09-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Excited state proton transfer in the red fluorescent protein mKeima. J.Am.Chem.Soc., 131, 2009
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2BJC
| NMR structure of a protein-DNA complex of an altered specificity mutant of the lac repressor headpiece that mimics the gal repressor | Descriptor: | 5'-D(*GP*AP*AP*TP*TP*GP*TP*AP*AP*GP *CP*GP*CP*TP*TP*AP*CP*AP*AP*TP*TP*C)-3', LACTOSE OPERON REPRESSOR | Authors: | Salinas, R.K, Folkers, G.E, Bonvin, A.M.J.J, Das, D, Boelens, R, Kaptein, R. | Deposit date: | 2005-02-01 | Release date: | 2005-10-18 | Last modified: | 2020-01-15 | Method: | SOLUTION NMR | Cite: | Altered Specificity in DNA Binding by the Lac Repressor: A Mutant Lac Headpiece that Mimics the Gal Repressor Chembiochem, 6, 2005
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1HRA
| THE SOLUTION STRUCTURE OF THE HUMAN RETINOIC ACID RECEPTOR-BETA DNA-BINDING DOMAIN | Descriptor: | RETINOIC ACID RECEPTOR, ZINC ION | Authors: | Knegtel, R.M.A, Katahira, M, Schilthuis, J.G, Bonvin, A.M.J.J, Boelens, R, Eib, D, Van Der Saag, P.T, Kaptein, R. | Deposit date: | 1993-07-25 | Release date: | 1994-01-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of the human retinoic acid receptor-beta DNA-binding domain. J.Biomol.NMR, 3, 1993
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2MUT
| Solution structure of the F231L mutant ERCC1-XPF dimerization region | Descriptor: | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF | Authors: | Faridounnia, M, Wienk, H, Kovacic, L, Folkers, G.E, Jaspers, N.G.J, Kaptein, R, Hoeijmakers, J.H.J, Boelens, R. | Deposit date: | 2014-09-17 | Release date: | 2015-06-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex. J.Biol.Chem., 290, 2015
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1CCN
| DIRECT NOE REFINEMENT OF CRAMBIN FROM 2D NMR DATA USING A SLOW-COOLING ANNEALING PROTOCOL | Descriptor: | CRAMBIN | Authors: | Bonvin, A.M.J.J, Rullmann, J.A.C, Lamerichs, R.M.J.N, Boelens, R, Kaptein, R. | Deposit date: | 1993-04-14 | Release date: | 1993-10-31 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Direct NOE refinement of biomolecular structures using 2D NMR data J.Biomol.NMR, 1, 1991
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1CCM
| DIRECT NOE REFINEMENT OF CRAMBIN FROM 2D NMR DATA USING A SLOW-COOLING ANNEALING PROTOCOL | Descriptor: | CRAMBIN | Authors: | Bonvin, A.M.J.J, Rullmann, J.A.C, Lamerichs, R.M.J.N, Boelens, R, Kaptein, R. | Deposit date: | 1993-04-14 | Release date: | 1993-10-31 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | "Ensemble" iterative relaxation matrix approach: a new NMR refinement protocol applied to the solution structure of crambin. Proteins, 15, 1993
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3RJ9
| Structure of alcohol dehydrogenase from Drosophila lebanonesis T114V mutant complexed with NAD+ | Descriptor: | Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Morgunova, E, Wuxiuer, Y, Cols, N, Popov, A, Sylte, I, Karshikoff, A, Gonzales-Duarte, R, Ladenstein, R, Winberg, J.O. | Deposit date: | 2011-04-15 | Release date: | 2012-05-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity. Febs J., 279, 2012
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1L1M
| SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1 | Descriptor: | 5'-D(*AP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*TP*T)-3', Lactose operon repressor | Authors: | Kalodimos, C.G, Bonvin, A.M.J.J, Salinas, R.K, Wechselberger, R, Boelens, R, Kaptein, R. | Deposit date: | 2002-02-19 | Release date: | 2002-06-26 | Last modified: | 2021-10-27 | Method: | SOLUTION NMR | Cite: | Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain. EMBO J., 21, 2002
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1GP1
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3RJ5
| Structure of alcohol dehydrogenase from Drosophila lebanonesis T114V mutant complexed with NAD+ | Descriptor: | ACETIC ACID, Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Morgunova, E, Wuxiuer, Y, Cols, N, Popov, A, Sylte, I, Karshikoff, A, Gonzales-Duarte, R, Ladenstein, R, Winberg, J.O. | Deposit date: | 2011-04-15 | Release date: | 2012-05-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity. Febs J., 279, 2012
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1HWT
| STRUCTURE OF A HAP1/DNA COMPLEX REVEALS DRAMATICALLY ASYMMETRIC DNA BINDING BY A HOMODIMERIC PROTEIN | Descriptor: | DNA (5'-D(*GP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*C)-3'), PROTEIN (HEME ACTIVATOR PROTEIN), ... | Authors: | King, D.A, Zhang, L, Guarente, L, Marmorstein, R. | Deposit date: | 1998-09-17 | Release date: | 1999-11-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein. Nat.Struct.Biol., 6, 1999
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3Q4C
| Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292 | Descriptor: | Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+) | Authors: | Xie, P, Streu, C, Qin, J, Pregman, H, Pagano, N, Meggers, E, Marmorstein, R. | Deposit date: | 2010-12-23 | Release date: | 2011-03-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. Biochemistry, 48, 2009
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1LQC
| LAC REPRESSOR HEADPIECE (RESIDUES 1-56), NMR, 32 STRUCTURES | Descriptor: | LAC REPRESSOR | Authors: | Slijper, M, Bonvin, A.M.J.J, Boelens, R, Kaptein, R. | Deposit date: | 1996-08-13 | Release date: | 1997-02-12 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Refined structure of lac repressor headpiece (1-56) determined by relaxation matrix calculations from 2D and 3D NOE data: change of tertiary structure upon binding to the lac operator. J.Mol.Biol., 259, 1996
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3LBX
| Crystal Structure of the Erythrocyte Spectrin Tetramerization Domain Complex | Descriptor: | Spectrin alpha chain, erythrocyte, Spectrin beta chain | Authors: | Ipsaro, J.J, Harper, S.L, Messick, T.E, Marmorstein, R, Mondragon, A, Speicher, D.W. | Deposit date: | 2010-01-08 | Release date: | 2010-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex. Blood, 115, 2010
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1E0E
| N-terminal zinc-binding HHCC domain of HIV-2 integrase | Descriptor: | HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 INTEGRASE, ZINC ION | Authors: | Eijkelenboom, A.P.A.M, Van Den ent, F.M.I, Plasterk, R.H.A, Kaptein, R, Boelens, R. | Deposit date: | 2000-03-25 | Release date: | 2001-03-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Refined Solution Structure of the Dimeric N-Terminal Hhcc Domain of HIV-2 Integrase J.Biomol.NMR, 18, 2000
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1E0H
| Inhibitor Protein Im9 bound to its partner E9 DNase | Descriptor: | IMMUNITY PROTEIN FOR COLICIN E9 | Authors: | Boetzel, R, Czisch, M, Kaptein, R, Hemmings, A.M, James, R, Kleanthous, C, Moore, G.R. | Deposit date: | 2000-03-28 | Release date: | 2000-10-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR investigation of the interaction of the inhibitor protein Im9 with its partner DNase. Protein Sci., 9, 2000
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1CJG
| NMR STRUCTURE OF LAC REPRESSOR HP62-DNA COMPLEX | Descriptor: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3'), PROTEIN (LAC REPRESSOR) | Authors: | Spronk, C.A.E.M, Bonvin, A.M.J.J, Radha, P.K, Melacini, G, Boelens, R, Kaptein, R. | Deposit date: | 1999-04-14 | Release date: | 2000-01-01 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator. Structure Fold.Des., 7, 1999
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1W29
| Lumazine Synthase from Mycobacterium tuberculosis bound to 3-(1,3,7- trihydro-9-D-ribityl-2,6,8-purinetrione-7-yl)butane 1-phosphate | Descriptor: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, 4-{2,6,8-TRIOXO-9-[(2R,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}BUTYL DIHYDROGEN PHOSPHATE, 4-{2,6,8-TRIOXO-9-[(2S,3R,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}BUTYL DIHYDROGEN PHOSPHATE, ... | Authors: | Morgunova, E, Meining, W, Illarionov, B, Haase, I, Fischer, M, Cushman, M, Bacher, A, Ladenstein, R. | Deposit date: | 2004-07-01 | Release date: | 2005-03-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,) Biochemistry, 44, 2005
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