2MUT

Solution structure of the F231L mutant ERCC1-XPF dimerization region

Summary for 2MUT

DescriptorDNA excision repair protein ERCC-1, DNA repair endonuclease XPF (2 entities in total)
Functional Keywordsercc1-xpf, f231l, nucleotide excision repair, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 3: Nucleus. Isoform 4: Nucleus P07992
Nucleus  Q92889
Total number of polymer chains2
Total molecular weight20216.19
Authors
Faridounnia, M.,Wienk, H.,Kovacic, L.,Folkers, G.E.,Jaspers, N.G.J.,Kaptein, R.,Hoeijmakers, J.H.J.,Boelens, R. (deposition date: 2014-09-17, release date: 2015-06-24, Last modification date: 2015-08-26)
Primary citation
Faridounnia, M.,Wienk, H.,Kovacic, L.,Folkers, G.E.,Jaspers, N.G.,Kaptein, R.,Hoeijmakers, J.H.,Boelens, R.
The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex.
J.Biol.Chem., 290:20541-20555, 2015
PubMed: 26085086 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M114.635169
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers707.9%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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