1W29

Lumazine Synthase from Mycobacterium tuberculosis bound to 3-(1,3,7- trihydro-9-D-ribityl-2,6,8-purinetrione-7-yl)butane 1-phosphate

Summary for 1W29

• Entry DOI: 10.2210/pdb1w29/pdb
• Related: 1W19
• Descriptor: 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE, ACETIC ACID, 4-{2,6,8-TRIOXO-9-[(2R,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}BUTYL DIHYDROGEN PHOSPHATE, ... (7 entities in total)
• Functional Keywords: transferase, riboflavin biosynthesis, lumazine synthase, inhibitor binding
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 5
• Total formula weight: 85110.14

Authors

Morgunova, E.,Meining, W.,Illarionov, B.,Haase, I.,Fischer, M.,Cushman, M.,Bacher, A.,Ladenstein, R. (deposition date: 2004-07-01, release date: 2005-03-03, Last modification date: 2019-07-24)

• Primary citation: Morgunova, E.,Meining, W.,Illarionov, B.,Haase, I.,Jin, G.,Bacher, A.,Cushman, M.,Fischer, M.,Ladenstein, R.; Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,); Biochemistry, 44:2746-, 2005; PubMed: 15723519; DOI: 10.1021/BI047848A

Experimental method

X-RAY DIFFRACTION (2.3 Å)