3RJ5

Structure of alcohol dehydrogenase from Drosophila lebanonesis T114V mutant complexed with NAD+

Summary for 3RJ5

Entry DOI	10.2210/pdb3rj5/pdb
Related	1a4u 1b15
Descriptor	Alcohol dehydrogenase, ACETIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	short-chain dehydrogenases/reductases, oxidoreductase, detoxification, nad metabolism
Biological source	Scaptodrosophila lebanonensis (Fruit fly)
Total number of polymer chains	2
Total formula weight	56367.48
Authors	Morgunova, E.,Wuxiuer, Y.,Cols, N.,Popov, A.,Sylte, I.,Karshikoff, A.,Gonzales-Duarte, R.,Ladenstein, R.,Winberg, J.O. (deposition date: 2011-04-15, release date: 2012-05-02, Last modification date: 2023-09-13)
Primary citation	Wuxiuer, Y.,Morgunova, E.,Cols, N.,Popov, A.,Karshikoff, A.,Sylte, I.,Gonzalez-Duarte, R.,Ladenstein, R.,Winberg, J.O. An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity. Febs J., 279:2940-2956, 2012 Cited by PubMed: 22741949 DOI: 10.1111/j.1742-4658.2012.08675.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation