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PDB: 109 件
8SFP
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BU of 8sfp by Molmil
WT CRISPR-Cas12a with the target strand in the RuvC active site.
分子名称: CRISPR-associated endonuclease Cas12a, DNA (40-MER), DNA (5'-D(P*CP*TP*TP*CP*CP*GP*AP*TP*CP*TP*TP*TP*TP*AP*GP*TP*GP*AP*TP*A)-3'), ...
著者Strohkendl, I, Taylor, D.W.
登録日2023-04-11
公開日2024-07-03
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献WT CRISPR-Cas12a with the target strand in the RuvC active site.
To Be Published
8T6O
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BU of 8t6o by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 0 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-16
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T7S
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BU of 8t7s by Molmil
SpRYmer bound to NAC PAM DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-21
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8FD8
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BU of 8fd8 by Molmil
human 15-PGDH with NADH bound
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
著者Huang, W, Taylor, D.
登録日2022-12-02
公開日2023-03-08
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.
Nat Commun, 14, 2023
4CMQ
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BU of 4cmq by Molmil
Crystal structure of Mn-bound S.pyogenes Cas9
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION
著者Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A.
登録日2014-01-17
公開日2014-02-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation
Science, 343, 2014
4CMP
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BU of 4cmp by Molmil
Crystal structure of S. pyogenes Cas9
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, SULFATE ION
著者Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A.
登録日2014-01-16
公開日2014-02-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
Science, 343, 2014
8SRS
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BU of 8srs by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-05-06
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T6S
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BU of 8t6s by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 10 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-18
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T6T
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BU of 8t6t by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 13 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-18
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8SQH
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BU of 8sqh by Molmil
SpRY-Cas9:gRNA complex targeting TTC PAM DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-05-04
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.69 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T6Y
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BU of 8t6y by Molmil
SpRY-Cas9:gRNA complex bound to non-target DNA with 1 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T76
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BU of 8t76 by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 3 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T78
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BU of 8t78 by Molmil
SpRY-Cas9:gRNA complex bound to non-target DNA with 8 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.02 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T77
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BU of 8t77 by Molmil
SpRY-Cas9:gRNA complex bound to non-target DNA with 6 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8SPQ
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BU of 8spq by Molmil
SpRY-Cas9:gRNA complex targeting TGG PAM DNA
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-05-03
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T6P
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BU of 8t6p by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 2 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-16
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T6X
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BU of 8t6x by Molmil
SpRY-Cas9:gRNA complex targeting TAC PAM DNA with 18 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8T79
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BU of 8t79 by Molmil
SpRY-Cas9:gRNA complex bound to non-target DNA with 10 bp R-loop
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Hibshman, G.N, Bravo, J.P.K, Taylor, D.W.
登録日2023-06-20
公開日2024-05-08
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8D4A
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BU of 8d4a by Molmil
Cas12a2 quaternary complex
分子名称: DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ...
著者Bravo, J.P.K, Taylor, D.W.
登録日2022-06-01
公開日2023-01-18
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.74 Å)
主引用文献RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2.
Nature, 613, 2023
8S9V
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BU of 8s9v by Molmil
CRISPR-Cas type III-D effector complex bound to a self-target RNA in the pre-cleavage state
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
Nat Commun, 15, 2024
8S9X
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BU of 8s9x by Molmil
CRISPR-Cas type III-D effector complex bound to self-target RNA in a post-cleavage state
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
Nat Commun, 15, 2024
8S9T
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BU of 8s9t by Molmil
CRISPR-Cas type III-D effector complex
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.52 Å)
主引用文献RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
Nat Commun, 15, 2024
8S9U
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BU of 8s9u by Molmil
CRISPR-Cas type III-D effector complex bound to a target RNA
分子名称: CRISPR RNA, Cas10, Cas7-2x, ...
著者Schwartz, E.A, Taylor, D.W.
登録日2023-03-30
公開日2024-04-24
実験手法ELECTRON MICROSCOPY (2.77 Å)
主引用文献Type III CRISPR-Cas effectors act as protein-assisted ribozymes
To Be Published
8DFS
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BU of 8dfs by Molmil
type I-C Cascade bound to AcrIF2
分子名称: Anti-CRISPR protein 30, CRISPR-associated protein, CT1133 family, ...
著者O'Brien, R.E, Bravo, J.P.K, Ramos, D, Hibshman, G.N, Wright, J.T, Taylor, D.W.
登録日2022-06-22
公開日2023-02-22
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural snapshots of R-loop formation by a type I-C CRISPR Cascade.
Mol.Cell, 83, 2023
8DFO
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BU of 8dfo by Molmil
type I-C Cascade bound to AcrIC4
分子名称: AcrIC4, CRISPR-associated protein, CT1133 family, ...
著者O'Brien, R.E, Bravo, J.P.K, Ramos, D, Hibshman, G.N, Wright, J.T, Taylor, D.W.
登録日2022-06-22
公開日2023-02-15
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural snapshots of R-loop formation by a type I-C CRISPR Cascade.
Mol.Cell, 83, 2023

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件を2024-07-17に公開中

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