8CWL

Cryo-EM structure of Human 15-PGDH in complex with small molecule SW222746

Summary for 8CWL

• Entry DOI: 10.2210/pdb8cwl/pdb
• EMDB information: 27010 27025
• Descriptor: 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-methyl-6-[7-(piperidine-1-carbonyl)quinoxalin-2-yl]isoquinolin-1(2H)-one (3 entities in total)
• Functional Keywords: dehydrogenase, inhibitor, oxidoreductase, oxidoreductase-inhibitor complex
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 57623.61

Authors

Huang, W.,Taylor, D.J. (deposition date: 2022-05-19, release date: 2023-03-08)

• Primary citation: Huang, W.,Li, H.,Kiselar, J.,Fink, S.P.,Regmi, S.,Day, A.,Yuan, Y.,Chance, M.,Ready, J.M.,Markowitz, S.D.,Taylor, D.J.; Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.; Nat Commun, 14:784-784, 2023; PubMed: 36774348; DOI: 10.1038/s41467-023-36463-7

Experimental method

ELECTRON MICROSCOPY (2.9 Å)