8CWL
Cryo-EM structure of Human 15-PGDH in complex with small molecule SW222746
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | polymer | 255 | 27747.9 | 2 | UniProt (P15428) Pfam (PF00106) | Homo sapiens (human) | 15-PGDH,Eicosanoid/docosanoid dehydrogenase [NAD(+)],Prostaglandin dehydrogenase 1,Short chain dehydrogenase/reductase family 36C member 1 |
| 2 | C, E (A, B) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 2 | Chemie (NAI) | |||
| 3 | D, F (A, B) | 2-methyl-6-[7-(piperidine-1-carbonyl)quinoxalin-2-yl]isoquinolin-1(2H)-one | non-polymer | 398.5 | 2 | Chemie (RLD) |
Sequence modifications
A, B: 3 - 256 (UniProt: P15428)
| PDB | External Database | Details |
|---|---|---|
| Met 2 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55495.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2127.8 | |
| All* | Total formula weight | 57623.6 |
