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8CWL

Cryo-EM structure of Human 15-PGDH in complex with small molecule SW222746

Functional Information from GO Data
ChainGOidnamespacecontents
A0001822biological_processkidney development
A0004957molecular_functionprostaglandin E receptor activity
A0005615cellular_componentextracellular space
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006693biological_processprostaglandin metabolic process
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007565biological_processfemale pregnancy
A0007567biological_processparturition
A0016323cellular_componentbasolateral plasma membrane
A0016404molecular_function15-hydroxyprostaglandin dehydrogenase (NAD+) activity
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019372biological_processlipoxygenase pathway
A0030728biological_processovulation
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0045471biological_processresponse to ethanol
A0045786biological_processnegative regulation of cell cycle
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
A0070403molecular_functionNAD+ binding
A0070493biological_processthrombin-activated receptor signaling pathway
A0097070biological_processductus arteriosus closure
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A1905828biological_processregulation of prostaglandin catabolic process
B0001822biological_processkidney development
B0004957molecular_functionprostaglandin E receptor activity
B0005615cellular_componentextracellular space
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006693biological_processprostaglandin metabolic process
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007565biological_processfemale pregnancy
B0007567biological_processparturition
B0016323cellular_componentbasolateral plasma membrane
B0016404molecular_function15-hydroxyprostaglandin dehydrogenase (NAD+) activity
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0019372biological_processlipoxygenase pathway
B0030728biological_processovulation
B0032355biological_processresponse to estradiol
B0032496biological_processresponse to lipopolysaccharide
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0045471biological_processresponse to ethanol
B0045786biological_processnegative regulation of cell cycle
B0051287molecular_functionNAD binding
B0070062cellular_componentextracellular exosome
B0070403molecular_functionNAD+ binding
B0070493biological_processthrombin-activated receptor signaling pathway
B0097070biological_processductus arteriosus closure
B1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
B1905828biological_processregulation of prostaglandin catabolic process
Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SlaglmpvaqQpvYCASKHGIvGFTrSAA
ChainResidueDetails
ASER138-ALA166

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
ATYR151
BTYR151

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:21072165
ChainResidueDetails
AGLY12
BASN91
BTYR151
BVAL186
AASP36
ACYS63
AASN91
ATYR151
AVAL186
BGLY12
BASP36
BCYS63

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
ASER138
AGLN148
BSER138
BGLN148

222415

PDB entries from 2024-07-10

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