6BF9
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![BU of 6bf9 by Molmil](/molmil-images/mine/6bf9) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain | Descriptor: | Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-10-26 | Release date: | 2018-02-07 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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6BF7
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![BU of 6bf7 by Molmil](/molmil-images/mine/6bf7) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain | Descriptor: | Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-10-26 | Release date: | 2018-02-07 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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6C6D
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![BU of 6c6d by Molmil](/molmil-images/mine/6c6d) | |
6B70
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![BU of 6b70 by Molmil](/molmil-images/mine/6b70) | Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin | Descriptor: | FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ... | Authors: | Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J. | Deposit date: | 2017-10-03 | Release date: | 2017-12-27 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7, 2018
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2JBU
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![BU of 2jbu by Molmil](/molmil-images/mine/2jbu) | Crystal structure of human insulin degrading enzyme complexed with co- purified peptides. | Descriptor: | 1,4-DIETHYLENE DIOXIDE, CO-PURIFIED PEPTIDE, INSULIN-DEGRADING ENZYME | Authors: | Im, H, Shen, Y, Tang, W.J. | Deposit date: | 2006-12-11 | Release date: | 2007-07-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282, 2007
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4DWK
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![BU of 4dwk by Molmil](/molmil-images/mine/4dwk) | Structure of cystein free insulin degrading enzyme with compound bdm41671 ((s)-2-{2-[carboxymethyl-(3-phenyl-propyl)-amino]-acetylamino}-3-(1h-imidazol-4-yl)-propionic acid methyl ester) | Descriptor: | Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2012-02-24 | Release date: | 2013-04-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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4DTT
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![BU of 4dtt by Molmil](/molmil-images/mine/4dtt) | Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367 | Descriptor: | 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, Insulin-degrading enzyme, ZINC ION | Authors: | Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. | Deposit date: | 2012-02-21 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79, 2014
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4M1C
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![BU of 4m1c by Molmil](/molmil-images/mine/4m1c) | Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) | Descriptor: | Amyloid beta A4 protein, Fab-bound IDE, heavy chain, ... | Authors: | McCord, L.M, Liang, W, Farcasanu, M, Scherpelz, K, Meredith, S.C, Koide, S, Tang, W.J. | Deposit date: | 2013-08-02 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.5007 Å) | Cite: | Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) To be Published
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4L3T
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![BU of 4l3t by Molmil](/molmil-images/mine/4l3t) | Crystal Structure of Substrate-free Human Presequence Protease | Descriptor: | ACETATE ION, GLYCEROL, Presequence protease, ... | Authors: | King, J.V, Liang, W.G, Tang, W.J. | Deposit date: | 2013-06-06 | Release date: | 2013-07-03 | Last modified: | 2014-07-23 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Molecular basis of substrate recognition and degradation by human presequence protease. Structure, 22, 2014
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4NGE
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![BU of 4nge by Molmil](/molmil-images/mine/4nge) | Crystal Structure of Human Presequence Protease in Complex with Amyloid-beta (1-40) | Descriptor: | ACETATE ION, Beta-amyloid protein 40, GLYCEROL, ... | Authors: | King, J.V, Liang, W.G, Tang, W.J. | Deposit date: | 2013-11-01 | Release date: | 2014-05-14 | Last modified: | 2014-07-23 | Method: | X-RAY DIFFRACTION (2.704 Å) | Cite: | Molecular basis of substrate recognition and degradation by human presequence protease. Structure, 22, 2014
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