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PDB: 907 件

6PAY
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Structure of HsICDH1:Mg(II):ICT:NADPH(50%) complex reveals structural basis for observation of half-sites reactivity
分子名称: FORMIC ACID, ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, ...
著者Silvaggi, N.R, Melkonian, T.R, Roman, J.V, Moran, G.R.
登録日2019-06-12
公開日2019-09-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Transient-State Analysis of Human Isocitrate Dehydrogenase I: Accounting for the Interconversion of Active and Non-Active Conformational States.
Biochemistry, 58, 2019
6CTH
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Crystal Structure of Pathogenesis-related Protein 1G (PR-1G) Kinase Domain from Cacao
分子名称: ACETATE ION, Concanavalin A-like lectin protein kinase family protein, MAGNESIUM ION, ...
著者Tosarini, T.R, Profeta, G.S, dos Reis, C.V, Counago, R.M, Massirer, K.B, Edwards, A.M, Elkins, J.M, Structural Genomics Consortium (SGC)
登録日2018-03-23
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of Pathogenesis-related Protein 1G (PR-1G) Kinase Domain from Cacao
To Be Published
5K68
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BU of 5k68 by Molmil
Designed Artificial Cupredoxins
分子名称: Streptavidin, [CuII(biot-bu-dpea)]2+
著者Mann, S.I, Heinisch, T, Weitz, A.C, Hendrich, M.R, Ward, T.R, Borovik, A.S.
登録日2016-05-24
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Modular Artificial Cupredoxins.
J.Am.Chem.Soc., 138, 2016
5CVS
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BU of 5cvs by Molmil
GlgE isoform 1 from Streptomyces coelicolor E423A mutant soaked in maltoheptaose
分子名称: Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Rashid, A.M, Syson, K, Koliwer-Brandl, H, van de Weerd, R, Stevenson, C.E.M, Batey, S.F.D, Miah, F, Alber, M, Ioerger, T.R, Chandra, G, Appelmelk, B.J, Nartowski, K.P, Khimyak, Y.Z, Lawson, D.M, Jacobs, W.R, Geurtsen, J, Kalscheuer, R, Bornemann, S.
登録日2015-07-27
公開日2016-08-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Ligand-bound structures and site-directed mutagenesis identify the acceptor and secondary binding sites of Streptomyces coelicolor maltosyltransferase GlgE.
J.Biol.Chem., 291, 2016
4RGW
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Crystal Structure of a TAF1-TAF7 Complex in Human Transcription Factor IID
分子名称: GLYCEROL, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 7
著者Wang, H, Curran, E.C, Hinds, T.R, Wang, E.H, Zheng, N.
登録日2014-09-30
公開日2014-12-03
最終更新日2014-12-17
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.
Cell Res., 24, 2014
2J8T
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BU of 2j8t by Molmil
Human aldose reductase in complex with NADP and citrate at 0.82 angstrom
分子名称: ALDO-KETO REDUCTASE FAMILY 1, MEMBER B1, CITRATE ANION, ...
著者Biadene, M, Hazemann, I, Cousido, A, Ginell, S, Sheldrick, G.M, Podjarny, A, Schneider, T.R.
登録日2006-10-27
公開日2007-05-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (0.82 Å)
主引用文献The Atomic Resolution Structure of Human Aldose Reductase Reveals that Rearrangement of a Bound Ligand Allows the Opening of the Safety-Belt Loop.
Acta Crystallogr.,Sect.D, 63, 2007
6RMK
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Bacteriorhodopsin, dark state, cell 2, refined using the same protocol as sub-ps time delays
分子名称: Bacteriorhodopsin, RETINAL
著者Nass Kovacs, G, Colletier, J.-P, Gruenbein, M.L, Stensitzki, T, Batyuk, A, Carbajo, S, Doak, R.B, Ehrenberg, D, Foucar, L, Gasper, R, Gorel, A, Hilpert, M, Kloos, M, Koglin, J, Reinstein, J, Roome, C.M, Schlesinger, R, Seaberg, M, Shoeman, R.L, Stricker, M, Boutet, S, Haacke, S, Heberle, J, Domratcheva, T, Barends, T.R.M, Schlichting, I.
登録日2019-05-07
公開日2019-06-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Three-dimensional view of ultrafast dynamics in photoexcited bacteriorhodopsin.
Nat Commun, 10, 2019
4RWM
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Kuenenia stuttgartiensis hydroxylamine oxidoreductase cryoprotected with ethylene glycol
分子名称: 1,2-ETHANEDIOL, 1-[(4-cyclohexylbutanoyl)(2-hydroxyethyl)amino]-1-deoxy-D-glucitol, HEME C, ...
著者Dietl, A, Maalcke, W, Barends, T.R.M.
登録日2014-12-05
公開日2015-08-12
最終更新日2021-03-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献An unexpected reactivity of the P460 cofactor in hydroxylamine oxidoreductase.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
4UAQ
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Crystal structure of the accessory translocation ATPase, SecA2, from Mycobacterium tuberculosis
分子名称: Protein translocase subunit SecA 2
著者Swanson-Smith, S, Ioerger, T.R, Rigel, N.W, Miller, B.K, Braunstein, M, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2014-08-11
公開日2015-09-09
最終更新日2016-02-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.
J.Bacteriol., 198, 2015
4UX6
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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, INDUCIBLE, ...
著者Cheshire, D.R, Andrews, G, Beaton, H.G, Birkinshaw, T, Boughton-Smith, N, Connolly, S, Cook, T.R, Cooper, A, Cooper, S.L, Cox, D, Dixon, J, Gensmantel, N, Hamley, P.J, Harrison, R, Hartopp, P, Kack, H, Luker, T, Mete, A, Millichip, I, Nicholls, D.J, Pimm, A.D, St-Gallay, S.A, Wallace, A.V.
登録日2014-08-19
公開日2014-10-08
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The Discovery of Novel, Potent and Highly Selective Inhibitors of Inducible Nitric Oxide Synthase (Inos).
Bioorg.Med.Chem.Lett., 21, 2011
4V66
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BU of 4v66 by Molmil
Structure of the E. coli ribosome and the tRNAs in Post-accommodation state
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Devkota, B, Caulfield, T.R, Tan, R.-Z, Harvey, S.C.
登録日2008-08-03
公開日2014-07-09
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (9 Å)
主引用文献The Structure of the E. coli Ribosome Before and After Accommodation: Implications for Proofreading
To be Published
4V65
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BU of 4v65 by Molmil
Structure of the E. coli ribosome in the Pre-accommodation state
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Devkota, B, Caulfield, T.R, Tan, R.-Z, Harvey, S.C.
登録日2008-08-03
公開日2014-07-09
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (9 Å)
主引用文献The Structure of the E. coli Ribosome Before and After Accommodation: Implications for Proofreading
To be Published
7LH9
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BU of 7lh9 by Molmil
Crystal structure of BRPF2 PWWP domain in complex with DNA
分子名称: Bromodomain-containing protein 1, DNA
著者Zhang, M, Lei, M, Qin, S, Dong, A, Yang, A, Li, Y, Loppnau, P, Hughes, T.R, Arrowsmith, C.H, Edwards, A.M, Min, J, Liu, J, Structural Genomics Consortium (SGC)
登録日2021-01-21
公開日2021-02-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Biochim Biophys Acta Gene Regul Mech, 1864, 2021
7M4O
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BU of 7m4o by Molmil
Crystal structure of phosphorylated RBR E3 ligase RNF216 in complex with K63-linked di-ubiquitin
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, E3 ubiquitin-protein ligase RNF216, GLYCEROL, ...
著者Cotton, T.R, Lechtenberg, B.C.
登録日2021-03-21
公開日2022-01-05
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
Mol.Cell, 82, 2022
7M4M
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BU of 7m4m by Molmil
Crystal structure of RBR E3 ligase RNF216 with ubiquitin
分子名称: E3 ubiquitin-protein ligase RNF216, GLYCEROL, Ubiquitin, ...
著者Cotton, T.R, Lechtenberg, B.C.
登録日2021-03-21
公開日2022-01-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
Mol.Cell, 82, 2022
7M4N
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BU of 7m4n by Molmil
Crystal structure of RBR E3 ligase RNF216 in complex with K63-linked di-ubiquitin
分子名称: E3 ubiquitin-protein ligase RNF216, GLYCEROL, SULFATE ION, ...
著者Cotton, T.R, Lechtenberg, B.C.
登録日2021-03-21
公開日2022-01-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
Mol.Cell, 82, 2022
7MX1
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BU of 7mx1 by Molmil
PLK-1 polo-box domain in complex with a high affinity macrocycle synthesized using a novel glutamic acid analog
分子名称: ACE-PRO-LEU-ALA-SER-TPO, N-[(4S)-4,5-diamino-5-oxopentyl]-10-phenyldecanamide, Serine/threonine-protein kinase PLK1
著者Grant, R.A, Hymel, D, Yaffe, M.B, Burke, T.R.
登録日2021-05-17
公開日2022-03-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles.
Org.Biomol.Chem., 19, 2021
7B5J
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BU of 7b5j by Molmil
Anti-CRISPR associated (Aca) protein, Aca2
分子名称: Anti-CRISPR associated (Aca) protein, Aca2, GLYCEROL
著者Usher, B, Birkholz, N, Fineran, P.C, Blower, T.R.
登録日2020-12-03
公開日2021-06-23
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Crystal structure of the anti-CRISPR repressor Aca2.
J.Struct.Biol., 213, 2021
7AEG
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SARS-CoV-2 main protease in a covalent complex with SDZ 224015 derivative, compound 5
分子名称: 3C-like proteinase, DIMETHYL SULFOXIDE, N-[(benzyloxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-L-alaninamide
著者Owen, C.D, Redhead, M.A, Lukacik, P, Strain-Damerell, C, Fearon, D, Brewitz, L, Collette, A, Robinson, C, Collins, P, Radoux, C, Navratilova, I, Douangamath, A, von Delft, F, Malla, T.R, Nugen, T, Hull, H, Tumber, A, Schofield, C.J, Hallet, D, Stuart, D.I, Hopkins, A.L, Walsh, M.A.
登録日2020-09-17
公開日2021-07-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.
Sci Rep, 11, 2021
7AEH
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SARS-CoV-2 main protease in a covalent complex with a pyridine derivative of ABT-957, compound 1
分子名称: (2~{R})-5-oxidanylidene-~{N}-[(2~{R},3~{S})-3-oxidanyl-4-oxidanylidene-1-phenyl-4-(pyridin-2-ylmethylamino)butan-2-yl]-1-(phenylmethyl)pyrrolidine-2-carboxamide, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE
著者Owen, C.D, Redhead, M.A, Lukacik, P, Strain-Damerell, C, Fearon, D, Brewitz, L, Collette, A, Robinson, C, Collins, P, Radoux, C, Navratilova, I, Douangamath, A, von Delft, F, Malla, T.R, Nugen, T, Hull, H, Tumber, A, Schofield, C.J, Hallet, D, Stuart, D.I, Hopkins, A.L, Walsh, M.A.
登録日2020-09-17
公開日2021-07-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.
Sci Rep, 11, 2021
7ALX
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Sav-SOD: Chimeric Streptavidin-cSOD as Host for Artificial Metalloenzymes
分子名称: ((4S)-1,3-dimesityl-4-((5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)methyl)imidazolidin-2-yl)gold, Streptavidin,Superoxide dismutase [Cu-Zn],Streptavidin
著者Igareta, N.V, Christoffel, F, Peterson, R.L, Ward, T.R.
登録日2020-10-07
公開日2021-07-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis
Nat Catal, 4, 2021
7B04
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Structure of Nitrite oxidoreductase (Nxr) from the anammox bacterium Kuenenia stuttgartiensis.
分子名称: CALCIUM ION, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, ...
著者Moreno-Chicano, T, Dietl, A, Akram, M, Barends, T.R.M.
登録日2020-11-18
公開日2021-07-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Structural and functional characterization of the intracellular filament-forming nitrite oxidoreductase multiprotein complex
Nat Microbiol, 2021
8QO4
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Conserved Structures and Dynamics in 5-Proximal Regions of Betacoronavirus RNA Genomes
分子名称: MERS-CoV-SL5
著者Moura, T.R, Purta, E, Bernat, A, Baulin, E, Mukherjee, S, Bujnicki, J.M.
登録日2023-09-28
公開日2024-03-06
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Conserved structures and dynamics in 5'-proximal regions of Betacoronavirus RNA genomes.
Nucleic Acids Res., 52, 2024
8QO2
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Conserved Structures and Dynamics in 5-Proximal Regions of Betacoronavirus RNA Genomes
分子名称: OC43-CoV-SL5
著者Moura, T.R, Purta, E, Bernat, A, Baulin, E, Mukherjee, S, Bujnicki, J.M.
登録日2023-09-27
公開日2024-03-06
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (7.1 Å)
主引用文献Conserved structures and dynamics in 5'-proximal regions of Betacoronavirus RNA genomes.
Nucleic Acids Res., 52, 2024
8QO3
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Conserved Structures and Dynamics in 5-Proximal Regions of Betacoronavirus RNA Genomes
分子名称: RoBat-CoV-SL5
著者Moura, T.R, Purta, E, Bernat, A, Baulin, E, Mukherjee, S, Bujnicki, J.M.
登録日2023-09-28
公開日2024-03-06
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (6.6 Å)
主引用文献Conserved structures and dynamics in 5'-proximal regions of Betacoronavirus RNA genomes.
Nucleic Acids Res., 52, 2024

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